Clinical Experiment of H. Pylori Transmission - Full Text View

Clinical Experiment of H. Pylori Transmission (SIFT-EPEC)

This study is currently recruiting participants.
Verified by Stanford University, October 2007

Sponsored by:	Stanford University
Information provided by:	Stanford University
ClinicalTrials.gov Identifier:	NCT00549224

Purpose

The study proposes to test whether chronic infection with Helicobacter pylori protects individuals from symptomatic infection with enteropathogenic E. coli. The study will also evaluate the effect of gastric acidity in this relationship.

Condition	Intervention
Helicobacter Pylori Infection Achlorhydria	Biological: Enteropathogenic E. coli

MedlinePlus related topics:

Diarrhea

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Other, Non-Randomized, Open Label, Single Group Assignment

Official Title:	Effect of Gastric Acid and H. Pylori Infection on Infection With Enteropathogenic E. Coli

Further study details as provided by Stanford University:

Primary Outcome Measures:

Development of diarrhea [ Time Frame: 48 hours after ingestion of E. coli ]

Secondary Outcome Measures:

Intensity of diarrhea [ Time Frame: 48 hours after ingestion of E. coli ]

Estimated Enrollment:	60
Study Start Date:	August 2005
Estimated Study Completion Date:	February 2008

Intervention Details:

Both study arms, those infected with H. pylori and those without infection will ingest 1 x 10^9 enteropathogenic E. coli

Eligibility

Ages Eligible for Study:	35 Years to 59 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy

Exclusion Criteria:

prior gastrointestinal disease
prior treatment of H. pylori infection
immune suppression or deficiency
history of cancer, diabetes, or other co-morbidity

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00549224

Contacts


Contact: Julie Parsonnet, MD	650-725-4561	parsonnt@stanford.edu

Contact: Alicia H. Chang, MD, MS	650-724-4941	achang2@stanford.edu

Locations


United States, California
	Stanford University	Recruiting
	Stanford, California, United States, 94305
	Principal Investigator: Julie Parsonnet, MD

Sponsors and Collaborators

Stanford University

Investigators


Principal Investigator:	Julie Parsonnet, MD	Stanford University

More Information

Study ID Numbers:	18489, DK53689 PAFYB
First Received:	October 23, 2007
Last Updated:	October 24, 2007
ClinicalTrials.gov Identifier:	NCT00549224
Health Authority:	United States: Institutional Review Board

Keywords provided by Stanford University:

Helicobacter pylori

hypochlorhydria

EPEC

enteropathogenic

achlorhydria

Study placed in the following topic categories:

Bacterial Infections

Metabolic Diseases

Digestive System Diseases

Stomach Diseases

Gastrointestinal Diseases

Achlorhydria

Helicobacter Infections

Metabolic disorder

Gram-Negative Bacterial Infections

Additional relevant MeSH terms:

Communicable Diseases

Infection

Acid-Base Imbalance

ClinicalTrials.gov processed this record on September 05, 2008