Trial record 7 of 30 for:    " September 19, 2007":" October 19, 2007"[FIRST-RECEIVED-DATE]AND HIV[CONDITION]

Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

This study has been completed.
Sponsor:
Information provided by:
UPECLIN HC FM Botucatu Unesp
ClinicalTrials.gov Identifier:
NCT00546689
First received: October 18, 2007
Last updated: April 17, 2008
Last verified: October 2007
  Purpose

Correlation between intestinal parasites and serum level of eosinophils and IgE in individuals with HIV or aids attended at clinical hospital of the Botucatu Medical School-UNESP


Condition
HIV Infections

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

Resource links provided by NLM:


Further study details as provided by UPECLIN HC FM Botucatu Unesp:

Primary Outcome Measures:
  • all [ Time Frame: one year ]

Secondary Outcome Measures:
  • all [ Time Frame: one year ]

Biospecimen Retention:   Samples Without DNA

Sample of Blood Sample of Feces


Enrollment: 30
Study Start Date: March 2007
Study Completion Date: August 2007
Groups/Cohorts
1 , 2
those with HIV

Detailed Description:

The present study correlates intestinal parasitism and levels of eosonophils and of serum IgEs in patients attended at the C.H. of the School of Medicine - Botucatu/UNESP. Thirty adult patients with AIDS were analyzed in the use of HAART, aged 42 ±11 years, 14 (46.7%) male, excluding those that had used anthelminthics 30 days prior to collection. Socioeconomic questionaires were applied and 3 samples of feces were taken for parasitological exams (TF-test® method) and 5 ml of blood for counting eosinophils (automated hematological counter, Pentra 80, ABX) and IgE doses (equipment BN-100, Dade-Behring). The index of parasites was 10%, with E.nana (3.3%), E.coli (3.3%) and B.hominis (3.3%). Parasitized individuals were from an urban region with complete basic sanitation and good socioeconomic level. Normal eosinphil values were found in all samples and increased IgE values in 1 (33.3%) sample. The index of parasites was low due to good socioeconomic level and disease control. Augmented IgE levels corroborate the literature, which reports an increase characteristic of immune response in the face of parasitic infections in individuals with HIV or AIDS. In conclusion, new studies should be undertaken to evaluate the level of eosinophils associated with cytokines to obtain a better understanding of this correlation.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

primary care clinic

Criteria

Inclusion Criteria:

  • HIV or AIDS
  • age same or superior to 18 years,
  • both sexes
  • assisted by the Hospital of the Clinics of Botucatu Medical School-UNESP

Exclusion Criteria:

  • use of anthelminthic in the period of 30 days antecedents the it dates from collection
  • individuals that don't have all of the necessary evaluations to the objectives of the study
  • individuals that abandon the attendance, or that you/they are to death during the study
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00546689

Sponsors and Collaborators
UPECLIN HC FM Botucatu Unesp
Investigators
Study Chair: Paulo C Pereira, Phd Botucatu Medical School - UNESP
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00546689     History of Changes
Other Study ID Numbers: upeclin/HC/FMB-Unesp-02, Botucatu Medical School UNESP
Study First Received: October 18, 2007
Last Updated: April 17, 2008
Health Authority: Brazil: National Committee of Ethics in Research
Brazil: National Health Surveillance Agency
Brazil: Ministry of Health

Keywords provided by UPECLIN HC FM Botucatu Unesp:
HIV
aids
intestinal parasites
eosinophils
immunoglobulins
HIV/aids
Treatment Experienced

Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Intestinal Diseases, Parasitic
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
Parasitic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases

ClinicalTrials.gov processed this record on July 22, 2014