• Pharmacokinetic profile [ Time Frame: Last patient out ] [ Designated as safety issue: No ]
  

• Tumor response, Tumor perfusion, Soluble markers of angiogenesis, Pharmacodynamics, Safety [ Time Frame: Last patient out ] [ Designated as safety issue: Yes ]
  

Liver metastases are among the most frequent neoplasms of the liver and represent a quite uniform clinical entity regardless from which carcinoma they originate. The treatment is dependent on number and size of the hepatic lesions but still, none of the therapeutic options leads to satisfying results. The growth of tumors and metastases is dependent on blood vessels, which supply the tumors and metastases with nutrients. Liver metastases, independent from which original tumor they come from, are especially well supplied with blood. The aim of the treatment with the investigational medicinal product EndoTAG®-1 is to target the blood vessels, which supply the metastases, and destroy them. Consequently, the metastases themselves will be damaged.

Inclusion Criteria:

• Unresectable hepatic metastases of a carcinomatous origin with exception of HCC, biliary or bile duct carcinoma
• At least one measurable hepatic metastases > 20 mm in diameter (measured in MRI)
• Last application of palliative chemotherapy (drug dependent on the primary tumor) at least 7 days ago
• Gender: male and female (at least 6 individuals of each gender)
• Age >= 18 years
• Negative pregnancy test (females of childbearing potential)
• Willingness to perform double-barrier-contraception during the study and for 6 month post study medication
• ECOG performance status 0,1 or 2
• Assumed life expectancy of > 3 month
• Signed informed consent

Exclusion Criteria:

• History of significant liver pathology (other than metastases, e.g. cirrhosis of the liver, PSC, PBC) or liver transplantation
• Laboratory tests (hematology, chemistry) outside specific limits:
• ANC <= 1.0 x 10^9/L
• Platelets <= 100 x 10^9/L
• Hb <= 9.0 g/dL (<= 5.6 mmol/L)
• Total Bilirubin > 2.0 mg/dL
• Serum Creatinine > 1.5 mg/dL
• Renal insufficiency with a GFR < 60 mL/min
• Currently ongoing taxane-containing palliative chemotherapy regimen or history of taxane administration within 4 weeks prior to study entry
• Pregnancy or nursing status
• Positive HIV, HBV or HCV testing
• The patient has a contraindication for MRI or CEUS according to accepted clinical guidelines
• Known hypersensitivity to any component of the EndoTAG®-1 formulation, gadolinium-based MR-contrast media or sulphur hexafluoride
• Claustrophobia or history of active or significant neurological disorder and/or psychiatric disorder that would prohibit the understanding and giving of informed consent, or would interfere in the clinical and radiological evaluation of the patient during the trial
• Concurrent treatment with other experimental drugs. Participation in another clinical trial with any investigational drug within 30 days prior to study entry