Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients. Secondary aims are to clarify the pathogenesis and the clinical relevance of mitochondrial damage during sepsis.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis|
- Mitochondrial respiratory chain enzyme activity [ Time Frame: On day one and seven from admission to ICU ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
muscle tissue, platelets, plasma
|Study Start Date:||October 2007|
|Study Completion Date:||August 2012|
|Primary Completion Date:||August 2011 (Final data collection date for primary outcome measure)|
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients, as compared to otherwise healthy surgical ones. In order to better clarify the pathogenesis of mitochondrial dysfunction during sepsis, cardiogenic shock patients (suffering from systemic hypoperfusion) will act as additional controls. Markers of oxidative stress will be measured in tissue samples from septic patients. The clinical relevance of mitochondrial dysfunction during sepsis will be assessed in terms of both skeletal muscle and platelet function.
|Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena|
|Milan, Italy, 20122|
|Study Chair:||Luciano Gattinoni, MD||Ospedale Maggiore Policlinico Mangiagalli e Regina Elena|
|Principal Investigator:||Alessandro Protti, MD||Ospedale Maggiore Policlinico Mangiagalli e Regina Elena|