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Trial record 6 of 52 for:    Open Studies | "Speech Disorders"
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Language in Primary Progressive Aphasia

This study is currently recruiting participants.
Verified April 2013 by Northwestern University
Sponsor:
Collaborator:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Marsel Mesulam, Northwestern University
ClinicalTrials.gov Identifier:
NCT00537004
First received: September 26, 2007
Last updated: April 2, 2013
Last verified: April 2013
History of Changes
  Purpose

The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.


Condition
Primary Progressive Aphasia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Language in Primary Progressive Aphasia

Resource links provided by NLM:

MedlinePlus related topics: Aphasia Dementia
U.S. FDA Resources

Further study details as provided by Northwestern University:

Primary Outcome Measures:
  • Neuropsychological variables [ Time Frame: Immediately after testing and at two years post-testing ] [ Designated as safety issue: No ]

Estimated Enrollment: 300
Study Start Date: May 2007
Estimated Study Completion Date: April 2017
Estimated Primary Completion Date: April 2017 (Final data collection date for primary outcome measure)
Groups/Cohorts
PPA
Individuals with primary progressive aphasia
Control
Individuals with no diagnosis of any type of dementia

Detailed Description:

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.

During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), an MRI (a non-invasive brain-imaging procedure), an EEG (another non-invasive procedure that looks at brain waves when you think) and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.

The study will recruit approximately 15 participants with PPA per year. For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.

Criteria

Inclusion Criteria:

  • Diagnosis of primary progressive aphasia
  • Right-handed
  • English speaker
  • Visual acuity of 20/30 corrected
  • Adequate hearing to follow conversation
  • Safe for an MRI scan

Exclusion Criteria:

  • Left-handedness
  • Claustrophobia
  • Presence of significant medical illness that initially or in the future could interfere with continued participation in the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00537004

Contacts
Contact: Christina Wieneke 312-908-9681 c-wieneke@northwestern.edu

Locations
United States, Illinois
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Christina Wieneke     312-908-9681     c-wieneke@northwestern.edu    
Principal Investigator: M.-Marsel Mesulam, MD            
Sponsors and Collaborators
Northwestern University
National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
Principal Investigator: Marsel Mesulam, MD Northwestern University Feinberg School of Medicine
  More Information

Additional Information:
Primary Progressive Aphasia (PPA) Research Program at Northwestern University  This link exits the ClinicalTrials.gov site

Publications:

Responsible Party: Marsel Mesulam, Professor, Northwestern University
ClinicalTrials.gov Identifier: NCT00537004     History of Changes
Other Study ID Numbers: IA0125, 5R01DC008552-05, 1RO1DC008552-01
Study First Received: September 26, 2007
Last Updated: April 2, 2013
Health Authority: United States: Federal Government

Keywords provided by Northwestern University:
primary progressive aphasia
frontotemporal dementia
semantic dementia
 progressive nonfluent aphasia
progressive aphasia
frontotemporal lobar degeneration

Additional relevant MeSH terms:
Speech Disorders
Aphasia
Aphasia, Primary Progressive
Pick Disease of the Brain
Frontotemporal Dementia
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
 Dementia
Brain Diseases
Central Nervous System Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Frontotemporal Lobar Degeneration
TDP-43 Proteinopathies
Neurodegenerative Diseases
Proteostasis Deficiencies
Metabolic Diseases

ClinicalTrials.gov processed this record on May 19, 2013