Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

This study is ongoing, but not recruiting participants.

First Received: September 20, 2007 No Changes Posted

Sponsor:	Rudolf Foundation Clinic
Information provided by:	Rudolf Foundation Clinic
ClinicalTrials.gov Identifier:	NCT00533754

Purpose

The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.

Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.

Condition	Intervention
Age-Related Macular Degeneration	Procedure: drawing blood

Study Type:	Interventional
Study Design:	Basic Science, Single Blind (Outcomes Assessor), Placebo Control, Single Group Assignment
Official Title:	Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Resource links provided by NLM:

Genetics Home Reference related topics: X-linked juvenile retinoschisis Help Me Understand Genetics

MedlinePlus related topics: Macular Degeneration

U.S. FDA Resources

Further study details as provided by Rudolf Foundation Clinic:

Primary Outcome Measures:

higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals

Secondary Outcome Measures:

a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD

Study Start Date:	July 2006
Estimated Study Completion Date:	November 2007

Eligibility

Ages Eligible for Study:	55 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

man and women over 18 years old
Filled out informed consentBereitschaft zur Teilnahme
Diagnosis of non-exudative/ exudative age related macular dgeneneration

Exclusion Criteria:

inherited retinal diseases
other aquired retinal/ macular
missing informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00533754

Locations

Austria
Rudoulf foundation Clinic
Vienna, Austria, 1030

Sponsors and Collaborators

Rudolf Foundation Clinic

Investigators

Study Chair:

Susanne Binder, M.D.

Rudoulf Foundation Clinic

More Information

No publications provided

Study ID Numbers:	EK 06-076-VK, EK 06-076-VK
Study First Received:	September 20, 2007
Last Updated:	September 20, 2007
ClinicalTrials.gov Identifier:	NCT00533754 History of Changes
Health Authority:	Austria: Ethikkommission

Keywords provided by Rudolf Foundation Clinic:

age-related macular degeneration, genetics

Additional relevant MeSH terms:

Eye Diseases
Retinal Degeneration
Macular Degeneration
Retinal Diseases

ClinicalTrials.gov processed this record on February 08, 2010