Biomarker Analysis of Stress
The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2007 by National Institute of Environmental Health Sciences (NIEHS).
Recruitment status was Not yet recruiting
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
First received: September 6, 2007
Last updated: September 7, 2007
Last verified: September 2007
Physiological changes can occur from different types of stress as induced by an infection, an environmental toxicant exposure, or an emotional disturbance. The stress-induced effects can modify health by lessening defense mechanisms as maintained by the immune system. The ability of different forms of stress to alter physiological processes (body functions) will be assessed by monitoring the blood profile of cell numbers and functions as well as the plasma protein content. It is anticipated that the pattern of blood changes will reflect the types of stress and the degree to which body functions could be altered by the stress.
||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
||Biomarker Signatures of Biological, Chemical, or Psychological Stress
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
Blood will be collected from patients with an ongoing infection that has lead to sepsis (systemic inflammation) as a index of major stress. The blood will be analyzed for the types of proteins that could alter immune system functions and affect organ functions, including cardiovascular effects due to blood vessel changes. This will be followed by analysis of stress effects on mice and mice that have been generated with human immune cells. The ability of stress to alter blood patterns will also be examined in mice with genetic modification of metallothionein expression, which is believe to influence oxidative stress.
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
- Patients at Wadsworth Center with Sepsis
Please refer to this study by its ClinicalTrials.gov identifier: NCT00527384
|Contact: David A. Lawrence, Ph.D.
|Albany, New York, United States, 12201 |
||David A. Lawrence, Ph.D.
No publications provided
History of Changes
|Other Study ID Numbers:
|Study First Received:
||September 6, 2007
||September 7, 2007
||United States: Federal Government
Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on April 23, 2014
Systemic Inflammatory Response Syndrome