Pulse Corticosteroid Therapy and Effect on Brain Water Diffusivity
Recruitment status was Recruiting
In daily clinical use, pulse high dosis corticosteroids are used to treat cerebral edema in different pathological situations ( surgery, trauma, tumors...). Dehydration can theorically concern extra-cellular or intracellular water, or both.
The relative proportion of those two components are not known, as well their kinetics.
Diffusion Weighted Imaging ( DWI) is a none invasive and none toxic technique to study those phenomena.We can also study the diffusivity anisotropy not using a Gaussian distribution but rather a non- gaussian one, more close to the reality ( q Space Imaging ).
Finally, we can study the compartment redistribution between slow and rapid water molecules diffusion by bi-exponential decomposition of the diffusion signal, corresponding, theorically, respectively to the intra- and extra-cellular component.
Hypothesis : The high dosis steroid pulse therapy modifies or not the water free diffusion in DWI and qSI ? Is there a modification in the diffusivity of both rapid and slow component ?
Systemic Lupus Erythematosus
|Study Design:||Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
|Contact: Thierry Duprez, MD||+ 32 2 764 29 email@example.com|
|Contact: Denis J Rommel, MDfirstname.lastname@example.org|
|Clinique Universitaire St LUC||Recruiting|
|Brussels, Belgium, 1200|
|Study Director:||Thierry Duprez, MD||Universite Catholique de Louvain|
|Principal Investigator:||Denis Rommel, MD||Universite Catholique de Louvain|