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| Sponsored by: |
University of Pittsburgh |
|---|---|
| Information provided by: | University of Pittsburgh |
| ClinicalTrials.gov Identifier: | NCT00524563 |
Purpose
The primary objective is to assess for independent predictors of in-hospital mortality (up to 28 days) in patients with Acinetobacter bloodstream infection. Secondary Objectives include the following: To determine the impact of inactive empiric antimicrobial therapy, defined as receipt of empiric antimicrobial therapy with no in vitro activity against the offending isolate for at least 24hrs, on the outcome (end points defined below) of patients with Acinetobacter bloodstream infection. To determine the impact of carbapenem resistance and pan-drug resistance (defined as resistance to all antimicrobials except colistin and/or tigecycline if these agents were tested) on the outcome of patients with Acinetobacter bloodstream infection. To assess the efficacy of varying definitive therapies on the outcome of patients with Acinetobacter bloodstream infection. To characterize the molecular epidemiology of Acinetobacter on a global level, as determined by pulsed-field gel electrophoresis (PFGE) and other techniques, and to assess whether patient outcomes are clonally related and to characterize the mechanisms of resistance in Acinetobacter on a global scale.
| Condition |
|---|
|
Acinetobacter Infections |
| Study Type: | Observational |
| Study Design: | Cohort, Retrospective |
| Official Title: | Clinical Outcomes and Global Epidemiology -Data Coordinating Center |
| Estimated Enrollment: | 400 |
| Study Start Date: | July 2007 |
Medical records will be reviewed and information collected from charts to assess for independent predictors of in-hospital mortality (up to 28 days) in patients with Acinetobacter bloodstream infection. 24 sites will participate and all information will be loaded into a password protected database.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
acinetobacter infection
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: David Paterson, MD | 412-648-6553 | david.antibiotics@gmail.com |
| Contact: Diana Lynn Pakstis, RN, BSN | 412-648-6553 | pakstisdl@dom.pitt.edu |
| United States, Pennsylvania | |
| University of Pittsburgh Medical Center | Recruiting |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| Contact: David Paterson, MD 412-648-6553 david.antibiotics@gmail.com | |
| Contact: Diana Lynn Pakstis, RN, BSN 412-648-6553 pakstisdl@dom.pitt.edu | |
| Principal Investigator: David Paterson, MD | |
| Sub-Investigator: Anton Peleg, MD | |
| Principal Investigator: | David Paterson, MD | University of Pittsburgh |
More Information
| Responsible Party: | UPMC ( David Paterson MD ) |
| Study ID Numbers: | PRO07080042 |
| Study First Received: | August 31, 2007 |
| Last Updated: | April 7, 2009 |
| ClinicalTrials.gov Identifier: | NCT00524563 History of Changes |
| Health Authority: | United States: Institutional Review Board |
|
Acinetobacter bloodstream infection Isolate |
|
Bacterial Infections Acinetobacter Infections Gram-Negative Bacterial Infections |
|
Bacterial Infections Acinetobacter Infections Infection Moraxellaceae Infections Gram-Negative Bacterial Infections |