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| Sponsored by: |
University of Aarhus |
| Information provided by: | University of Aarhus |
| ClinicalTrials.gov Identifier: | NCT00523835 |
Purpose
Klinefelter syndrome (KS) is the most common sex-chromosome disorder with a prevalence of one in 660 men and is a frequent cause of hypogonadism and infertility. It is caused by the presence of extra X-chromosomes, the most common karyotype being 47,XXY. The phenotype is variable, but the most constant finding is small hyalinized testes, hypergonadotrophic hypogonadism, infertility, eunuchoid body proportion, increased height and learning disabilities. Klinefelter syndrome has been associated with increased prevalence of diabetes, osteoporosis and cardiovascular diseases but the pathogenesis is unknown. Accordingly the aim of the study was to investigate measures of body composition, insulin sensitivity, bone mineral density, echocardiography, as well as biochemical markers of endocrine, metabolic and bone function in KS and an age-matched control group.
| Condition |
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Klinefelter Syndrome Diabetes Osteoporosis Metabolic Syndrome Cardiovascular Disease |
| Genetics Home Reference related topics: | Klinefelter syndrome |
| MedlinePlus related topics: | Diabetes Klinefelter's Syndrome Minerals Osteoporosis |
| ChemIDplus related topics: | Insulin |
| Study Type: | Observational |
| Study Design: | Natural History, Cross-Sectional, Convenience Sample, Prospective Study |
| Estimated Enrollment: | 140 |
| Study Start Date: | April 2002 |
| Study Completion Date: | November 2004 |
| Groups/Cohorts |
|
KS: Case
Patients with Klinefelter syndrome verified by chromosome analysis
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Normal: Control
Normal men Age matched to KS patients
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Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Denmark | |||||
| Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital | |||||
| Aarhus, Denmark, 8000 | |||||
| University of Aarhus |
| Study Chair: | Jens S. Christiansen, Professor | Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark |
| Principal Investigator: | Anders B Bojesen, MD, PhD | Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark |
| Study Director: | Claus H Gravholt, MD, DMsc, PhD | Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark |
More Information
| Study ID Numbers: | 20010155 |
| First Received: | August 31, 2007 |
| Last Updated: | August 31, 2007 |
| ClinicalTrials.gov Identifier: | NCT00523835 |
| Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
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