Biochemical Factors for a Dry Eyed Population (GARNET)
The purpose of this study is to compare various symptoms and signs of dry-eye as well as stratify characteristics of the tear film in a group of dry-eyed individuals in comparison to a group of non-dry-eyed people. Dry-eye is a condition that significantly impacts the quality of life of the sufferer. These are people who are predominantly female and in the older age groups. Determining what characterises a person with dry-eyes is of importance to understanding the disease process.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Biochemical Factors for a Dry Eyed Population|
|Study Start Date:||May 2007|
|Study Completion Date:||September 2007|
|Primary Completion Date:||September 2007 (Final data collection date for primary outcome measure)|
Dry eye is a multifactorial disease that results in a wide variety of signs and symptoms, which are often poorly correlated. Recent work has shown that not only are there changes in the composition of the tear film (including cytokines and the presence of various mucin species and tear film proteins) but also quantifiable changes in both the structure and function of the ocular surface, including corneal sensitivity and the appearance of the epithelial cells and the sub-basal neural network. To-date, no published study has attempted to correlate various clinical and morphological changes found in dry eye with tear film and ocular surface biomarkers.
|Centre for Contact Lens Research, School of Optometry|
|Waterloo, Ontario, Canada, N2L3G1|
|Principal Investigator:||Desmond Fonn, M.Optom||University of Waterloo|