T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients

This study has been completed.

Sponsor:

Information provided by:

Imperial College London

ClinicalTrials.gov Identifier:

NCT00520559

First received: August 23, 2007

Last updated: NA

Last verified: August 2007

History: No changes posted

Purpose

The purpose of this study is to provide accurate prognostic data linking cardiac complications to myocardial T2* values (A measure of iron levels in the heart using MRI)in patients predisposed to heart iron overload.

Condition
Thalassemia

Study Type:	Observational
Study Design:	Observational Model: Defined Population Observational Model: Natural History Time Perspective: Longitudinal Time Perspective: Retrospective
Official Title:	Incidence of Cardiac Complications in Patients With Cardiac Siderosis During 1 Year Follow−up and the Normal T2* Ranges in LVF, MI and Normal Population.

Resource links provided by NLM:

Genetics Home Reference related topics: African iron overload

MedlinePlus related topics: Anemia Thalassemia

U.S. FDA Resources

Further study details as provided by Imperial College London:

Enrollment:	665
Study Start Date:	January 2007
Study Completion Date:	August 2007

Show Detailed Description

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Thalassaemia Major
Patient must have had a cardiac MRI scan between 1999 and 2006

Exclusion Criteria:

Other structural heart disease such as valvular abnormalities, MI, congenital heart disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00520559

Sponsors and Collaborators

Imperial College London

Investigators

Principal Investigator:

Dudley Pennell, MA, MD

Imperial College London

More Information

No publications provided by Imperial College London

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Kirk P, He T, Anderson LJ, Roughton M, Tanner MA, Lam WW, Au WY, Chu WC, Chan G, Galanello R, Matta G, Fogel M, Cohen AR, Tan RS, Chen K, Ng I, Lai A, Fucharoen S, Laothamata J, Chuncharunee S, Jongjirasiri S, Firmin DN, Smith GC, Pennell DJ. International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers. J Magn Reson Imaging. 2010 Aug;32(2):315-9.

Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, Wu D, Taylor J, Westwood MA, Anderson LJ, Pennell DJ. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009 Nov 17;120(20):1961-8. Epub 2009 Oct 2.

ClinicalTrials.gov Identifier:	NCT00520559 History of Changes
Other Study ID Numbers:	07/MRE04/32
Study First Received:	August 23, 2007
Last Updated:	August 23, 2007
Health Authority:	United Kingdom: National Health Service United Kingdom: Research Ethics Committee

Additional relevant MeSH terms:

Thalassemia
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia

Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on May 19, 2013

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