• Detection of local and distant prostate cancer foci proven by histopathological results [ Time Frame: within <2 weeks after PET/MRI ] [ Designated as safety issue: No ]
  

Choline can be marked by a positron radiator (in this trial 18F) enabling a PET to detect the regional distribution of this substance in high local resolution. Due to the image-fusion of high resolution MRI, accumulations can be assigned exactly with anatomical structures, in order to facilitate a phase-adapted therapeutic treatment.

This study should prove, that Choline-PET/MRI is able to detect prostate cancer with a sensitivity of over 90% (9% accuracy, 95% confidence interval). PET/MRI results of 43 patients with histologically known prostate cancer (needle biopsy) will be correlated to the post-interventional histopathological results (radical prostatectomy).

Inclusion Criteria:

• histologically diagnosed prostate cancer (needle biopsy)
• radical prostatectomy as primary treatment
• no nutrition within 12 hours before PET
• no food containing choline within 24 hous before PET
• age >50 years

Exclusion Criteria:

• total endo-prothesis of the hip region
• clinical or chemical detection of an acute infection
• missing patient agreement
• secondary cancer
• surgical treatment within 3 month before PET
• claustrophobia
• medical drugs with choline
• severe liver damage
• cardiac infarction
• Bradycardia (pulse rate <55/min)
• allergic reaction against Neurotropan
• asthma bronchiale
• cardiac pacemaker
• each kind of small metal implants (e.g. clips, cochlea-implants, etc.)