Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis
Recruitment status was Recruiting
Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.
|Study Design:||Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective/Prospective
|Study Start Date:||December 2006|
|Estimated Study Completion Date:||December 2007|
There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.
|Contact: Kyung Hoon Paik, M.D.||email@example.com|
|Korea, Republic of|
|Samsung Medical Center||Recruiting|
|Seoul, Korea, Republic of, 135-710|
|Contact: Kyung Hoon Paik, M.D. 82-2-3410-1284 firstname.lastname@example.org|
|Principal Investigator:||Kyung Hoon Paik, M.D.||Samsung Medical Center, Sungkyunkwan University School of Medicine|