Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard

This study has been completed.
Information provided by:
Baqiyatallah Medical Sciences University Identifier:
First received: August 13, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted

to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation

Condition Intervention Phase
Chronic Obstructive Pulmonary Disease
Drug: helium:oxygen
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Supportive Care

Resource links provided by NLM:

Further study details as provided by Baqiyatallah Medical Sciences University:

Primary Outcome Measures:
  • assess spirometry and hemodynamic measures after heliox or air:oxygen use

Study Start Date: February 2007
Estimated Study Completion Date: June 2007

Ages Eligible for Study:   38 Years to 59 Years
Genders Eligible for Study:   Male

Inclusion Criteria:

  • a history of previous exposure to sulfur mustard
  • worsening dyspnea during the last 10 days
  • respiratory rate >25/min
  • arterial pH<7.35
  • PaCO2 of >50 mmHg
  • PaO2 of <50 mmHg

Exclusion Criteria:

  • recent pneumothorax (<1 month)
  • severe respiratory failure or hemodynamic instability with forthcoming intubation
  • FIO2 of <0.4
  • impaired consciousness or absence of patient cooperation
  • facial lesions precluding NIV
  Contacts and Locations
Please refer to this study by its identifier: NCT00515606

Sponsors and Collaborators
Baqiyatallah Medical Sciences University
Study Director: Mostafa Ghanei, MD Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University
  More Information

No publications provided Identifier: NCT00515606     History of Changes
Other Study ID Numbers: 210586
Study First Received: August 13, 2007
Last Updated: August 13, 2007
Health Authority: Iran: Baqiyatallah Medical Sciences University

Additional relevant MeSH terms:
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Respiratory Insufficiency
Bronchial Diseases
Respiratory Tract Diseases
Respiratory Tract Infections processed this record on April 16, 2014