Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis
Recruitment status was Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract. The origin of Crohn's disease remains unknown and there is no curative therapy, either medical or surgical, for this gut disorder.
It is believed that an infectious agent is important in the development of Crohn's disease. The similarity of Crohn's disease to the animal form of ileitis, termed Johne's disease, supports the possibility that both disorders are caused by exposure to Mycobacterium avium paratuberculosis or MAP. Multiple investigators have demonstrated good clinical responses of patients with Crohn's disease to treatment with triple antibiotic therapy directed against mycobacterial infection.
The hypothesis of this protocol is that triple antibiotic therapy is useful as a medical therapy for patients with Crohn's disease. The aim of this study is to examine the response of patients with Crohn's disease who are not receiving therapy with biological agents to triple antibiotic therapy.
| Condition | Intervention | Phase |
|---|---|---|
|
Crohn's Disease |
Drug: Rifabutin, Clarithromycin, and Clofazimine |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis |
- Clinical remission by a decline in Crohns disease activity index to <151 [ Time Frame: 6 Months ]
- Clinical improvement using inflammatory bowel disease quality of life questionnaire [ Time Frame: 6 Months ]
- Endoscopic improvement using Crohn's disease endoscopic activity index [ Time Frame: 6 Months ]
| Estimated Enrollment: | 20 |
| Study Start Date: | January 2007 |
| Estimated Study Completion Date: | March 2008 |
-
Drug: Rifabutin, Clarithromycin, and Clofazimine
Clinical remission will be determined by a decline in the Crohns disease activity index to <151; clinical improvement will be examined using the inflammatory bowel disease (IBD) quality of life questionnaire; and endoscopic improvement will be examined using a Crohn's disease endoscopic activity index. All individuals must have had colonoscopy within 3 months of enrollment. An estimated 20 individuals will be enrolled in this protocol. Each patient will be treated for 6 months with a combination of rifabutin, clarithromycin, and clofazimine. At the end of 6 months of treatment for each patient, the Crohns disease activity index will be recalculated, each patient will again complete the IBD quality of life questionnaire, and each patient will undergo repeat colonoscopy.
Eligibility| Ages Eligible for Study: | 18 Years to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- This study will only include patients capable of providing informed consent, ages 18 and older.
- Patients must have a documented diagnosis of Crohn's disease and have had a colonoscopy with photographs within 3 months prior to randomization.
- All patients must have a CDAI of 220 or greater at enrollment.
- All females must be post-menopausal, surgically sterilized, or either abstain from sexual intercourse or use a non-hormonal method of birth control other than or in addition to oral contraceptive during the study and for 6 weeks after the end of the study.
Exclusion Criteria:
- Any patient with ulcerative colitis
- All women of child-bearing age must have a negative urine pregnancy test within 1 week prior to the initial clinic visit.
- Patients receiving a biological therapy for Crohn's disease including remicade
- Patients with a known allergy to any of the three antibiotics used in this protocol.
Contacts and Locations| Contact: Timothy R Koch, M.D. | 202-877-7108 | timothy.r.koch@medstar.net |
| United States, District of Columbia | |
| Washington Hospital Center | Recruiting |
| Washington, District of Columbia, United States, 20010 | |
| Principal Investigator: Timothy R Koch, MD | |
| Principal Investigator: | Timothy R Koch, MD | Washington Hospital Center |
More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00513552 History of Changes |
| Other Study ID Numbers: | 2006-257, FDA IND 75,897 |
| Study First Received: | August 6, 2007 |
| Last Updated: | August 7, 2007 |
| Health Authority: | United States: Food and Drug Administration |
Additional relevant MeSH terms:
|
Mycobacterium Infections Mycobacterium avium-intracellulare Infection Mycobacterium Infections, Atypical Crohn Disease Paratuberculosis Inflammatory Bowel Diseases Gastroenteritis Gastrointestinal Diseases Digestive System Diseases Intestinal Diseases Actinomycetales Infections Gram-Positive Bacterial Infections Bacterial Infections Anti-Bacterial Agents Clofazimine |
Clarithromycin Rifabutin Anti-Infective Agents Therapeutic Uses Pharmacologic Actions Leprostatic Agents Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Central Nervous System Agents |
ClinicalTrials.gov processed this record on May 23, 2013