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Postoperative Cognitive Dysfunction in Geriatric Patients

This study is currently recruiting participants.
Verified June 2011 by University Hospital, Basel, Switzerland
Sponsor:
Information provided by:
University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT00512200
First received: August 6, 2007
Last updated: June 29, 2011
Last verified: June 2011
History of Changes
  Purpose

Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.


Condition
Delirium, Dementia, Amnestic, Cognitive Disorders
Age
Postoperative Complications
Memory Disorders

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Postoperative Cognitive Dysfunction in Geriatric Patients: the Role of Intraoperative Cerebral Perfusion and Perioperative Anticholinergic Medication

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital, Basel, Switzerland:

Estimated Enrollment: 300
Study Start Date: July 2007
Groups/Cohorts
Case
Patients aged 65 or older
Control
Patients aged 20 to 40
Control 2
Healthy volunteers aged 65 or older

  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients undergoing elective major surgery under general anesthesia

Criteria

Inclusion Criteria:

  • Elective surgical procedure under general anaesthesia

Exclusion Criteria:

  • History of cerebrovascular disease
  • Mini Mental status <23
  • Cardiac surgery
  • Neurosurgery
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00512200

Contacts
Contact: Luzius A Steiner, MD, PhD ++41 (0)61 265 2525 luzius.steiner@chuv.ch

Locations
Switzerland
Department of Anaesthesia, University Hospital Basel Recruiting
Basel, BS, Switzerland, 4031
Principal Investigator: Luzius A Steiner, MD PhD            
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
Principal Investigator: Luzius A Steiner, MD PhD Department of Anaesthesia, University Hospital Basel
  More Information

No publications provided

Responsible Party: Department of Anesthesia
ClinicalTrials.gov Identifier: NCT00512200     History of Changes
Other Study ID Numbers: EK 75/07
Study First Received: August 6, 2007
Last Updated: June 29, 2011
Health Authority: Switzerland: Federal Office of Public Health

Additional relevant MeSH terms:
Memory Disorders
Cognition Disorders
Delirium
Dementia
Delirium, Dementia, Amnestic, Cognitive Disorders
Postoperative Complications
Mental Disorders
Confusion
 Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Brain Diseases
Central Nervous System Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on May 19, 2013