Hemodynamic Parameters in Euthyroid Patients With Thyroid Nodules

This study has been terminated.
(The received reliability with increase in quantity of participants of research did not vary)
Sponsor:
Information provided by:
Yaroslavl State Medical Academy
ClinicalTrials.gov Identifier:
NCT00507897
First received: July 25, 2007
Last updated: February 6, 2008
Last verified: February 2008
  Purpose

The purpose of this study is to determine the relationship of hemodynamic parameters with the level of thyroid hormones and the histological structure of thyroid nodules in euthyroid patients.


Condition
Thyroid Nodules

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Yaroslavl State Medical Academy:

Estimated Enrollment: 100
Study Completion Date: December 2007
Groups/Cohorts
A
Cohort: Patients with normal blood pressure scheduled to have thyroid nodules surgically removed
A1
Patients from group A not receiving any drugs and who lack other pathology, gender and age matched group B1
B
Cohort: Patients with increased blood pressure scheduled to have thyroid nodules surgically removed
B1
Patients from group B not receiving any drugs and who lack other pathology, gender and age matched group A1

Detailed Description:

As opposed to widely investigated condition of cardiovascular system in patients with functional disorders of thyroid gland, the relationship between thyroid hormones and hemodynamic parameters in euthyroid patients remains not enough clear.

We detect the parameters of blood pressure and thyroid hormones in euthyroid patients with thyroid nodules directly before planned operation on the thyroid gland.

As the study is carries out directly before operation, that assumes presence of preoperative stress in patients, activity of the sympatho - adrenal system is estimated in addition.

On the one hand, the design of our research will allow to estimate relationship of thyroid hormones with the parameters of blood pressure in conditions of euthyroidism, on the other hand - to investigate features of blood pressure in patients with thyroid nodules.

The research of the patients in the preoperative period will enable to select the group of patients without pathology of cardiovascular system whose increased blood pressure is connected with preoperative stress, that in turn will allow to exclude influence of the pathology of the cardiovascular system on studied correlation.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Euthyroid patients with thyroid nodules before operation on the thyroid gland

Exclusion Criteria:

  • Hyperthyroidism
  • Hypothyroidism
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00507897

Locations
Russian Federation
Yaroslavl State Medical Academy
Yaroslavl, Russian Federation, 150000
Sponsors and Collaborators
Yaroslavl State Medical Academy
Investigators
Study Chair: Yuriy Alexandrov, Professor Yaroslavl State Medical Academy
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00507897     History of Changes
Other Study ID Numbers: ESheverdova-1
Study First Received: July 25, 2007
Last Updated: February 6, 2008
Health Authority: Russia: Ethics Committee

Keywords provided by Yaroslavl State Medical Academy:
thyroid nodules, blood pressure, thyroid hormones

Additional relevant MeSH terms:
Thyroid Diseases
Thyroid Nodule
Endocrine System Diseases
Thyroid Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Neoplasms
Head and Neck Neoplasms

ClinicalTrials.gov processed this record on October 19, 2014