Postanesthesia Cognitive Recovery and Neuropsychologic Complications - Full Text View

Postanesthesia Cognitive Recovery and Neuropsychologic Complications

This study is currently recruiting participants.
Verified by University of Roma La Sapienza, May 2007

Sponsored by:	University of Roma La Sapienza
Information provided by:	University of Roma La Sapienza
ClinicalTrials.gov Identifier:	NCT00507195

Purpose

The study proposes to analyze the difference in the rapidity of the recovery of post operative cognition immediately after extubation and 20, 40 and 60 minutes post extubation and neuropsychological complications (delirium) after 48 hours following general anesthesia using a prospective, randomized approach. Patients undergoing any type of surgery with the exception of cranial, cardiac or thoracic surgery can be enrolled in the study.

Condition	Intervention
Anesthesia Recovery Period Delirium, Dementia, Cognitive Disorders Neurobehavioural Manifestation Mental Competency	Drug: Hypnotics: propofol, sevoflurane, desflurane,desflurane,midazolam

MedlinePlus related topics:

Anesthesia Dementia

ChemIDplus related topics:

Midazolam Midazolam hydrochloride Midazolam maleate Propofol Sevoflurane I 653

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Convenience Sample, Prospective Study

Official Title:	Post Operative Cognitive Recovery and Neuropsychological Complications After General Anesthesia. A Comparison Between Different Techniques of Anesthesia: A Multi-Center Observational Study

Further study details as provided by University of Roma La Sapienza:

Estimated Enrollment:	1200
Study Start Date:	May 2007

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Adult age patients undergoing general anesthesia

Exclusion Criteria:

Cerebral and cardiac surgery
Surgical procedures required postoperative delayed extubation

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00507195

Contacts


Contact: Federico Bilotta, MD, PhD	39 339 33 708 22	bilotta@tiscali.it

Locations


Italy
	Azienda Policlinico Umberto I, University of Rome La Sapienza,	Recruiting
	Rome,, Italy, 00161
	Contact: Federico Bilotta, MD, PhD
	Principal Investigator: Federico Bilotta, MD, PhD

Sponsors and Collaborators

University of Roma La Sapienza

Investigators


Study Chair:	Federico Bilotta, MD, PhD	University of Roma La Sapienza

More Information

Study ID Numbers:	pinocchio
First Received:	July 23, 2007
Last Updated:	July 24, 2007
ClinicalTrials.gov Identifier:	NCT00507195
Health Authority:	Italy: Ethics Committee

Keywords provided by University of Roma La Sapienza:

Postanethesia cognitive recovery

Postoperative delirium

hypnotics

propofol

sevoflurane

desflurane

postoperative cognitive recovery

Study placed in the following topic categories:

Confusion

Midazolam

Cognition Disorders

Sevoflurane

Signs and Symptoms

Desflurane

Delirium, Dementia, Amnestic, Cognitive Disorders

Mental Disorders

Neurologic Manifestations

Dementia

Propofol

Neurobehavioral Manifestations

Delirium

Additional relevant MeSH terms:

Anesthetics, Intravenous

Neurotransmitter Agents

Tranquilizing Agents

Molecular Mechanisms of Pharmacological Action

GABA Modulators

Hematologic Agents

Nervous System Diseases

Physiological Effects of Drugs

Psychotropic Drugs

Anesthetics

Central Nervous System Depressants

Pharmacologic Actions

Adjuvants, Anesthesia

Anesthetics, Inhalation

Anesthetics, General

Therapeutic Uses

Hypnotics and Sedatives

GABA Agents

Platelet Aggregation Inhibitors

Anti-Anxiety Agents

Central Nervous System Agents

ClinicalTrials.gov processed this record on August 21, 2008