Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Information provided by (Responsible Party):
Weill Medical College of Cornell University
ClinicalTrials.gov Identifier:
NCT00504894
First received: July 19, 2007
Last updated: April 2, 2013
Last verified: April 2013
  Purpose

This study involves 90 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable. This dissociation pattern will be different between the drugs propofol and thiopental


Condition Intervention Phase
Healthy
Drug: Thiopental
Drug: Propofol
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Official Title: Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Resource links provided by NLM:


Further study details as provided by Weill Medical College of Cornell University:

Primary Outcome Measures:
  • Performance on memory tasks [ Time Frame: 2 hours after MRI ] [ Designated as safety issue: No ]

Estimated Enrollment: 90
Study Start Date: March 2007
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: A
Drug given in low dose to gauge subject's responses to visual stimuli.
Drug: Thiopental
A low dose given intravenously one time for just under an hour while the subject is shown visually stimulating images in an MRI machine.
Placebo Comparator: B
Thiopental administration
Drug: Propofol
A low dose given intravenously while the subject is shown visually stimulating images in an MRI machine.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age b/w 18 and 50
  • right-handed
  • minimum of high school education
  • fluent in English
  • normal vocabulary

Exclusion Criteria:

  • any significant medical/psychiatric comorbidity
  • deficit in vision or hearing that would impede the study
  • allergies to any of the study drugs, to soybeans, or eggs.
  • history of head trauma
  • family history of major psychiatric illness
  • body mass index > 30 kg/m2
  • claustrophobia
  • prior exposure to IAPS pictures
  • pregnancy
  • permanent metal objects anywhere in the body
  • a personal/family history of any porphyria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00504894

Locations
United States, New York
Weill Cornell Medical College
New York, New York, United States, 10065
Sponsors and Collaborators
Weill Medical College of Cornell University
Investigators
Principal Investigator: Kane Pryor, M.D. Weill Medical College of Cornell University
  More Information

No publications provided

Responsible Party: Weill Medical College of Cornell University
ClinicalTrials.gov Identifier: NCT00504894     History of Changes
Other Study ID Numbers: 0701008933, K08GM083213
Study First Received: July 19, 2007
Last Updated: April 2, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Weill Medical College of Cornell University:
N/A healthy volunteers

Additional relevant MeSH terms:
Anesthetics
Thiopental
Anesthetics, Intravenous
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Anesthetics, General
Anticonvulsants
Hypnotics and Sedatives
GABA Modulators
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on September 18, 2014