A Study of the Effects of Ketoconazole Taken Orally Has on the PK Profiles of a Dose of GSK189075 in Healthy Volunteers

Inclusion Criteria:

• Are a healthy, non-smoking male or female.
• Are 18 to 55 years old, inclusive.
• Have a body weight of > or equal to 110 pounds.
• Are a female who is unable to have any more children and have a negative pregnancy test.
• Are willing and able to provide written informed consent before the start of any study-related procedures.
• Are able to understand and comply with protocol requirements, instructions, and protocol-stated restrictions.

Exclusion Criteria:

• Smoke or use any tobacco products.
• Have a known allergic reaction to ketoconazole or study drug.
• Have a history of regular alcohol consumption greater than 7 drinks per week for females or greater than 14 drinks per week for males.
• Have a positive drug or alcohol or smoking test at screening or check-in to the clinic.
• Have participated in another clinical trial within 30 days prior to screening in which you have received an investigational drug.
• Have donated a pint of blood within 56 days before the first dose of study drug.
• Have any known or suspected stomach condition (or stomach surgery within the 6 months prior to dosing).
• Have abnormal liver test results.
• Have a documented history or diagnosis of cirrhosis.
• Have positive results for hepatitis C or B, or HIV at screening.
• Have blood pressure outside of the normal range.
• Are a male subject who is unwilling to either abstain from sexual activity or unwilling to use birth control during the course of the study.
• Are using non-prescription drugs, vitamins, herbal or dietary supplements (including St John's Wort) within 7 days before the first dose of study medication,
• Have any abnormality identified on the screening physical or laboratory examination that the study physician feels would make it inappropriate for you to participate in the study.