Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study (MMS)

This study has been completed.
Sponsor:
Collaborator:
Ludwig-Maximilians - University of Munich
Information provided by:
Technische Universität München
ClinicalTrials.gov Identifier:
NCT00500773
First received: July 11, 2007
Last updated: April 30, 2014
Last verified: April 2014
  Purpose

The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and compare these findings with the effects of the extreme strains of marathon running. Subclinical injuries to heart and arteries are being investigated in different groups of runners, including obese participants.


Condition
Modes of Exercise and Myocardial and Endothelial Function
Microcirculation
Subclinical Endorgan Damage
Obesity

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Investigation of Myocardial Injury, Ventricular Dysfunction and Cardiovascular Risk Factors in Different Groups of Marathon Runners

Resource links provided by NLM:


Further study details as provided by Technische Universität München:

Enrollment: 60
Study Start Date: July 2007
Study Completion Date: May 2008
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
Detailed Description:

Regular exercise leads to an improvement of cardiovascular risc factors in patients with coronary heart disease, atherosclerosis and metabolic disorders. Aerobic exercise has anti-inflammatory effects. In contrast, the exertional exercise of marathon running causes an acute pro-inflammatory impulse. This may lead to myocardial injury and, in case of preexisting plaques, may result in plaque rupture and acute myocardial infarction.

The researchers aim to define the critical role of inflammatory markers and cardiovascular risk factors as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon runners.

The study groups are divided into average trained runners (40 km/week), average trained obese runners and highly trained runners (> 70km/week). Training programmes are supervised by professional coaches. Individual scientific marathon contests are organized for the assessments.

Diagnostic tools include measurements of pulse wave velocity and heart rate turbulence, echocardiography and, for the first time, MRI-scans pre- and post marathon running. Additionally, cardiovascular markers such as endothelial progenitor cells (EPCs)and adiponectin are measured. Inflammatory markers include c-reactive protein (CRP), interleukins and tumor necrosis factor.

  Eligibility

Ages Eligible for Study:   30 Years to 60 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy male marathon runners with no more than one treated cardiovascular risk factor aged 30-60 years. Participation of at least a 1/2 marathon in recent history.

Criteria

Inclusion Criteria:

  • Men aged 30-60 years
  • Obese subjects: BMI > 27 and waist circumference > 102cm

Exclusion Criteria:

  • manifested heart disease
  • insulin dependent diabetes mellitus
  • multiple drug therapy
  • GFR < 60 ml/min.
  • claustrophobia
  • metal implants
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00500773

Locations
Germany
Department of Prevention and Sportsmedicine, Technical University of Munich
Connollystrasse 32, Munich, Bavaria, Germany, 80809
Sponsors and Collaborators
Technische Universität München
Ludwig-Maximilians - University of Munich
Investigators
Principal Investigator: Henner Hanssen, MD Department of Prevention and Sportmedicine, Technical University Munich
  More Information

Additional Information:
No publications provided

Responsible Party: Dr. med. Henner Hanssen, Lehrstuzl für Praeventive und rehabilitative Sportmedizin
ClinicalTrials.gov Identifier: NCT00500773     History of Changes
Other Study ID Numbers: 1807/07
Study First Received: July 11, 2007
Last Updated: April 30, 2014
Health Authority: Germany: Ethics Commission

Keywords provided by Technische Universität München:
cardiovascular risc factors
inflammation
aerobic and exertional exercise

ClinicalTrials.gov processed this record on September 22, 2014