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Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2010 by University of Leipzig.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Leipzig
ClinicalTrials.gov Identifier:
NCT00497887
First received: July 6, 2007
Last updated: October 18, 2010
Last verified: January 2010
History of Changes
  Purpose

Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.


Condition
Atherosclerosis
Coronary Arteriosclerosis
Carotid Artery Diseases
Genetic Predisposition to Disease
Biological Markers

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Leipzig:

Biospecimen Retention:   Samples With DNA

serum, plasma, whole blood (DNA), blood cells


Estimated Enrollment: 4000
Study Start Date: December 2006
  Eligibility

Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients assigned to coronary angiography

Criteria

Inclusion Criteria:

  • Patients assigned to coronary angiography

Exclusion Criteria:

  • Cancer
  • Acute myocardial infarction
  • Inability to give informed consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00497887

Contacts
Contact: Joachim Thiery, MD PhD +49-341-9722201 thiery@medizin.uni-leipzig.de
Contact: Gerhard Schuler, MD PhD +49-341-8650 schug@medizin.uni-leipzig.de

Locations
Germany
University of Leipzig, Heart Center, Department of Cardiology Recruiting
Leipzig, Germany, 04289
Contact: Gerhard Schuler, MD PhD     +49-341-8650        
Contact: Stephan Gielen, MD PhD     +49-341-8650        
Principal Investigator: Gerhard Schuler, MD PhD            
Sub-Investigator: Stephan Gielen, MD PhD            
Sub-Investigator: Frank Beutner, MD PhD            
Sub-Investigator: Marcus Sandri, MD PhD            
University of Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics Recruiting
Leipzig, Germany, 04103
Contact: Joachim Thiery, MD PhD     +49-341-9722201     thiery@medizin.uni-leipzig.de    
Contact: Daniel Teupser, MD PhD     +49-341-9722204     teupser@medizin.uni-leipzig.de    
Principal Investigator: Joachim Thiery, MD PhD            
Sub-Investigator: Daniel Teupser, MD PhD            
Sub-Investigator: Frank Beutner, MD PhD            
Sub-Investigator: Alexander Leichtle, MD PhD            
Sub-Investigator: Ralph Burkhardt, MD PhD            
Sub-Investigator: Lesca M Holdt, MD PhD            
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Joachim Thiery, MD PhD University of Leipzig
  More Information

Additional Information:
University Hospital Leipzig, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics  This link exits the ClinicalTrials.gov site
University of Leipzig, Heart Center  This link exits the ClinicalTrials.gov site

No publications provided by University of Leipzig

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Joachim Thiery, Daniel Teupser, Stephan Gielen, Gerhard Schuler, University Leipzig
ClinicalTrials.gov Identifier: NCT00497887     History of Changes
Other Study ID Numbers: 276-2005
Study First Received: July 6, 2007
Last Updated: October 18, 2010
Health Authority: Germany: Ethics Commission

Additional relevant MeSH terms:
Arteriosclerosis
Atherosclerosis
Carotid Artery Diseases
Coronary Artery Disease
Myocardial Ischemia
Disease Susceptibility
Genetic Predisposition to Disease
Arterial Occlusive Diseases
Vascular Diseases
 Cardiovascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Coronary Disease
Heart Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on May 16, 2013