Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2007 by Devathasan Neurology Practice Pte Ltd.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Devathasan Neurology Practice Pte Ltd
ClinicalTrials.gov Identifier:
NCT00494689
First received: June 28, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted
  Purpose

The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia and dilated ventricles who improve when treated with transcranial monitoring or low ultrasound wave intensity (milliwatts) and with rapid magnetic stimulation which is also a diagnostic tool routinely used by many neurophysiologists. Before, these patients will progress and may need a brain shunt called Ventriculo-peritoneal shunt. He and collaborators now would like to do a double study as this appears to be a cheap and effective alternative treatment and help patients to walk again.


Condition
Walking
Cognitive Function

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Longitudinal

Resource links provided by NLM:


Further study details as provided by Devathasan Neurology Practice Pte Ltd:

Estimated Enrollment: 30
Study Start Date: January 2002
Estimated Study Completion Date: June 2007
Detailed Description:

The transcranial monitoring intensity would be equivalent to the well known CLOTBUST study (<300mw/sq cm)for one hour, using two probes.

All will be treated as an outpatient and there is no form of infusion or interventional treatment.

The rapid magnetic stimulation is at about 50a/us, 15Hz, 1000 pulses with 10 sec pause for ten days along the skull vault. Informed consent will be obtained. 30 patients will be recruited and sham treatment would be just applying probe without power for transcranial and for magnetic stimulation coil will be angled away. Data will be compiled by a separate blinded investigator and so with the statistics. VP shunt failure patients, which is common, will be included. Barthel's daily living index and standard cognitive tests will be used to assess results.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • cerebral ischemia with our without hydrocephalus and gait apraxia

Exclusion Criteria:

  • all other conditions which contribute to walking difficulty e.g. bad knees; or spondylosis; parkinson's or paralytic strokes
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00494689

Contacts
Contact: Devathasan Gobinathan, FRCP,MD 65-67330311 devathasan@msn.com
Contact: Weng Kiong Ow Yong, Bsc 65-97970966 gdeva@yahoo.com

Locations
Singapore
Devathasan Neurology Practice Recruiting
Singapore, Singapore, 228510
Contact: Gobinathan Devathasan, FRCP    65-97304401    devathasan@msn.com   
Devathasan Neurology Practice #11-16 MEMC Recruiting
Singapore, Singapore, 228510
Principal Investigator: Devathasan Gobinathan, FRCP MD         
Sponsors and Collaborators
Devathasan Neurology Practice Pte Ltd
Investigators
Study Chair: Weng Kiong Aw Yong, Bsc (QUT) Freelancer Computer Programmer and data control
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00494689     History of Changes
Other Study ID Numbers: 02
Study First Received: June 28, 2007
Last Updated: June 28, 2007
Health Authority: Singapore: Health Science Authority
Canada: University of British Columbia; Dept of Science.

Keywords provided by Devathasan Neurology Practice Pte Ltd:
transcranial sonolysis or monitoring
rapid magnetic stimulation
cerebral ischemia
hydrocephalus
Barthel's index

Additional relevant MeSH terms:
Cerebral Infarction
Brain Ischemia
Hydrocephalus
Hydrocephalus, Normal Pressure
Brain Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Stroke
Vascular Diseases
Cardiovascular Diseases
Intracranial Hypertension

ClinicalTrials.gov processed this record on April 15, 2014