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Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-Wave Myocardial Infarction by MRI

This study has been completed.
Sponsor:
Information provided by:
Duke University
ClinicalTrials.gov Identifier:
NCT00493168
First received: June 26, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted
  Purpose

The first aim of this study is to determine how often unrecognized myocardial infarction occur in patients using a magnetic resonance imaging (MRI) technique (known as delayed enhancement MRI), as compared to the electrocardiogram. The second aim of this study is to determine the severity of coronary heart disease of the patients with unrecognized myocardial infarction. The final aim is to determine how the presence of unrecognized myocardial infarction detected by the MRI affects lifespan.


Condition
Coronary Arteriosclerosis
Myocardial Infarction

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Unrecognized Non-Q-Wave Myocardial Infarction: Prevalence, Angiographic Correlation, and Prognostic Significance in Patients With Suspected Coronary Disease

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Duke University:

Enrollment: 185
Study Start Date: January 1998
Study Completion Date: November 2006
Detailed Description:

Unrecognized myocardial infarction (MI) is known to constitute a substantial portion of lethal coronary heart disease. However, since the diagnosis of unrecognized MI is based on the appearance of incidental Q-waves on 12-lead electrocardiography, the syndrome of unrecognized non-Q-wave MI has not been described. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can accurately identify non-Q-wave MI. The aims of this study are three-fold: 1. to determine the prevalence of unrecognized non-Q-wave and Q-wave MI, 2. to define predictors of unrecognized non-Q-wave MI, 3. to determine the prognostic significance of unrecognized non-Q-wave MI.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with suspected coronary artery disease referred for invasive coronary angiography

Exclusion Criteria:

  • Clinical history of myocardial infarction
  • Percutaneous coronary intervention
  • Coronary artery bypass surgery
  • Known uncured malignancy
  • History of hypertrophic cardiomyopathy, myocarditis, or infiltrative heart disease
  • Contraindication of magnetic resonance imaging
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00493168

Locations
United States, Illinois
Northwestern University Medical School
Chicago, Illinois, United States, 60611
United States, North Carolina
Duke Cardiovascular Magnetic Resonance Center
Durham, North Carolina, United States, 27710
Sponsors and Collaborators
Duke University
Investigators
Principal Investigator: Han W Kim, MD Duke Cardiovascular Magnetic Resonance Center
Principal Investigator: Raymond J Kim, MD Duke Cardiovascular Magnetic Resonance Center
  More Information

No publications provided by Duke University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

ClinicalTrials.gov Identifier: NCT00493168     History of Changes
Other Study ID Numbers: Unrecognized MI
Study First Received: June 26, 2007
Last Updated: June 26, 2007
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Arteriosclerosis
Coronary Artery Disease
Myocardial Ischemia
Infarction
Myocardial Infarction
Arterial Occlusive Diseases
Vascular Diseases
 Cardiovascular Diseases
Coronary Disease
Heart Diseases
Ischemia
Pathologic Processes
Necrosis

ClinicalTrials.gov processed this record on May 21, 2013