Periodontal and Periapical Inflammation and Pregnancy

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Roger Johnson, University of Mississippi Medical Center
ClinicalTrials.gov Identifier:
NCT00490165
First received: June 20, 2007
Last updated: April 5, 2012
Last verified: April 2012
  Purpose

This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.


Condition
Periodontal Disease
Periapical Disease
Pregnancy
Diabetes
Cardiovascular Disease
Dental Caries

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes

Resource links provided by NLM:


Further study details as provided by University of Mississippi Medical Center:

Enrollment: 30
Study Start Date: March 2007
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   10 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.

Criteria

Inclusion Criteria:

  • Female
  • Child bearing age or above

Exclusion Criteria:

  • Male
  • Very young children (before child-bearing age)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00490165

Locations
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39202
Sponsors and Collaborators
Roger Johnson
Investigators
Principal Investigator: Jennifer L Bain, BS University of Mississippi Medical Center
Study Director: Roger Johnson, PhD; DMD University of Mississippi Medical Center
  More Information

No publications provided

Responsible Party: Roger Johnson, Professor, University of Mississippi Medical Center
ClinicalTrials.gov Identifier: NCT00490165     History of Changes
Other Study ID Numbers: 2006-0198
Study First Received: June 20, 2007
Last Updated: April 5, 2012
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Cardiovascular Diseases
Dental Caries
Inflammation
Periapical Diseases
Periodontal Diseases
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases
Pathologic Processes
Jaw Diseases
Mouth Diseases

ClinicalTrials.gov processed this record on July 23, 2014