Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

This study has been completed.
Sponsor:
Information provided by:
Mashhad University of Medical Sciences
ClinicalTrials.gov Identifier:
NCT00484250
First received: June 7, 2007
Last updated: June 8, 2007
Last verified: June 2007
  Purpose

Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.


Condition Intervention Phase
Oral Lichen Planus
Drug: metronidazole,doxycycline
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Mashhad University of Medical Sciences:

Enrollment: 20
Study Start Date: September 2005
Study Completion Date: May 2006
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

  • pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00484250

Locations
Iran, Islamic Republic of
Mashhad University Of Medical Sciences(Dentistry School)
Mashhad, Khorasan, Iran, Islamic Republic of, 91375345
Sponsors and Collaborators
Mashhad University of Medical Sciences
Investigators
Study Chair: Arash Mansourian, DDS,MS Tehran University of Medical Sciences
Study Director: Majid Sanatkhani, DDS,MS Mashhad University of Medical Sciences
Principal Investigator: Fatemeh Momen Heravi Tehran University of Medical Sciences
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00484250     History of Changes
Other Study ID Numbers: 240
Study First Received: June 7, 2007
Last Updated: June 8, 2007
Health Authority: Iran: Ministry of Health

Keywords provided by Mashhad University of Medical Sciences:
Oral Lichen Planus
Metronidazole
Doxycycline

Additional relevant MeSH terms:
Lichen Planus
Lichen Planus, Oral
Lichenoid Eruptions
Skin Diseases, Papulosquamous
Skin Diseases
Mouth Diseases
Stomatognathic Diseases
Metronidazole
Doxycycline
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions
Antiprotozoal Agents
Antiparasitic Agents
Radiation-Sensitizing Agents
Anti-Bacterial Agents
Antimalarials

ClinicalTrials.gov processed this record on September 16, 2014