Observational Study of Early Metabolic and Vascular Changes in Obesity (STYJOBS)
To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003. STYJOBS / EDECTA is a prospective, observational study to improve the understanding of atherosclerosis, cardiovascular risk, immune mediated low grade inflammation, and metabolic changes in obesity by investigation of the "non-biased" early phase.
The main focus is the early identification of obesity and "worse lifestyle" related individual high risk profiles for cardiovascular/metabolic/immune-inflammatory disease in juvenile, young, and adult persons up to the age of 65 years. Based on this information, new and effective strategies are developed for preclinical diagnostics and early intervention. Concerning mechanisms of obesity and "bad" lifestyle associated pathologic conditions, risk biomarker patterns, chronic immune-mediated inflammation, disturbed adipokine balance, individual adipose tissue topography, brown and white adipose tissue (BAT/WAT) function, addiction like behaviour, genetics/epigenetics (eg. role of miRNAs), early vascular pathology, and fatty liver disease are in focus of research. The interventional program consists of a holistic strategy comprehending sports, and lifestyle modification. An improved basic understanding of the role of a disturbed energy expenditure in the etiology of obesity should give the basis for new paradigms in therapy of obesity.
The investigative spectrum of STYJOBS / EDECTA was extended also to non-obese body weight extremes i.e. underweight/anorectic people.
Understanding of Early Settings to an Obesity "Career"
Vascular Burden in Obesity
Brown/White Adipose Tissue
Fatty Liver Disease
Other: Lifestyle modification
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Study for the Investigation of New Individual Risk Profiles and Therapeutic Strategies in Obesity Related Cardiovascular and Metabolic Disorders.|
- Anthropometric changes(BMI, SAT-Topography, waist/hipCF, waist to height ratio) during intervention [ Time Frame: 12 months ] [ Designated as safety issue: No ]
- Obesity related biomarkers (fasting glucose, insulin, HOMA-index, HbA1c, liver transaminases, inflammatory markers, adipokines, clotting parameters, lipids, oxidative stress markers, Biomarkers related to tryptophan metabolism), performance diagnostics. [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Collection of fasted blood samples between 9 and 12 AM.
|Study Start Date:||January 2003|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
The cohort consists of age and sex matched normal weighted controls and overweight/obese persons.
Definition for "overweight": BMI >90th and <97th percentile, if under 18 years of age, and BMI >25 and <29.9 kg/m2 if over 18 years of age.
Definition for "obese": BMI >97th percentile, if under 18 years of age, and BMI >30kg/m2, if over 18 years of age.
Other: Lifestyle modification
Regular sports and dietary advices. Controlled by analysis of laboratory parameters, BMI change and performance diagnostics. No drugs included so far.
Other Name: lifestyle counseling
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|Contact: Harald Mangge, Prof., MD||+43 316 385 ext email@example.com|
|Clinical Institute for Medical and Chemical Laboratory Diagnosis||Recruiting|
|Graz, Styria, Austria, 8036|
|Contact: Harald Mangge, Prof., MD +43316 385 ext 83340 firstname.lastname@example.org|
|Principal Investigator: Harald Mangge, Prof., MD|
|Principal Investigator:||Harald Mangge, Prof., MD||Medical University of Graz, Austria|