Non-Invasive Determination of Cardiac Output by Inertgas Rebreathing Method (NICO)

This study has been completed.
Sponsor:
Information provided by:
Universitätsmedizin Mannheim
ClinicalTrials.gov Identifier:
NCT00479804
First received: May 25, 2007
Last updated: June 4, 2008
Last verified: June 2008
  Purpose

The cardiac output (CO) is an important parameter in the diagnosis and therapy of cardiac diseases. The current standard methods for the determination of the CO, however, are either invasive (e.g. right heart catheterization) or technically expendable and expensive (magnetic resonance tomography, MRT). The traditional non-invasive methods of determining the CO by rebreathing of carbon dioxide are easily carried out but suffer from methodical inaccuracies. Therefore the aim of the study at hand was to evaluate a new method for determining the CO by means of the inert gas rebreathing method.


Condition Intervention
Cardiac Diseases
Device: inertgas rebreathing
Device: spirometry
Device: cardiac magnetic resonance imaging (CMR)

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Non-Invasive Determination of Cardiac Output by the Inertgas Rebreathing Method Compared With Magnetic Resonance Tomography

Resource links provided by NLM:


Further study details as provided by Universitätsmedizin Mannheim:

Enrollment: 311
Study Start Date: August 2006
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: inertgas rebreathing
    determination of cardiac output by inertgas rebreathing
    Device: spirometry
    spirometry for testing the ventilatory function
    Device: cardiac magnetic resonance imaging (CMR)
    CMR examination which delivers the hemodynamic reference parameters
  Eligibility

Ages Eligible for Study:   14 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Study Population

Consecutive patients with indication for CMR

Criteria

Inclusion Criteria:

  • Indication for CMR
  • Ability of following instructions for rebreathing test
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00479804

Locations
Germany
1st Department of Medicine, University Hospital Mannheim
Mannheim, Baden-Württemberg, Germany, 68167
Sponsors and Collaborators
Universitätsmedizin Mannheim
Investigators
Study Director: Joachim Saur, Dr. 1st Department of Medicine
Study Chair: Jens Kaden, Dr. 1st Deparment of Medicine
  More Information

No publications provided

Responsible Party: Dr. Joachim Saur, University Hospital Mannheim
ClinicalTrials.gov Identifier: NCT00479804     History of Changes
Other Study ID Numbers: 2006-067M-MA
Study First Received: May 25, 2007
Last Updated: June 4, 2008
Health Authority: Germany: Ethics Commission

Keywords provided by Universitätsmedizin Mannheim:
indication for CMR

Additional relevant MeSH terms:
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on July 22, 2014