Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

This study has been completed.

First Received: May 23, 2007 No Changes Posted

Sponsor:	Universita di Verona
Information provided by:	Universita di Verona
ClinicalTrials.gov Identifier:	NCT00477789

Purpose

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Condition	Intervention	Phase
Chronic Heart Failure	Drug: allopurinol	Phase IV

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title:	Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Resource links provided by NLM:

MedlinePlus related topics: Heart Failure

Drug Information available for: Allopurinol sodium Allopurinol

U.S. FDA Resources

Further study details as provided by Universita di Verona:

Primary Outcome Measures:

diastolic function uric acid levels BNP [ Time Frame: three months ]

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

chronic heart failure;
left ventricular systolic dysfunction (ejection fraction <45%)
stable clinical conditions in the previous three months
optimal medical therapy for CHF
normal sinus rhythm
written informed consent
age >18 years

Exclusion Criteria:

renal failure (s-creatinine >2.5 mg/dl)
already on allopurinol
malignancies
chronic inflammatory diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00477789

Locations

Italy
Division of Cardiology, University Hospital of Verona
Verona, Italy, 37129

Sponsors and Collaborators

Universita di Verona

Investigators

Principal Investigator:

Mariantonietta Cicoira, MD, PhD

Division of Cardiology, University of Verona, Italy

More Information

No publications provided

Study ID Numbers:	802
Study First Received:	May 23, 2007
Last Updated:	May 23, 2007
ClinicalTrials.gov Identifier:	NCT00477789 History of Changes
Health Authority:	Italy: Ethics Committee

Keywords provided by Universita di Verona:

chronic heart failure
diastolic dysfunction
uric acid

Additional relevant MeSH terms:

Antimetabolites
Heart Failure
Allopurinol
Heart Diseases
Antioxidants
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Enzyme Inhibitors

Protective Agents
Gout Suppressants
Pharmacologic Actions
Therapeutic Uses
Free Radical Scavengers
Cardiovascular Diseases
Antirheumatic Agents

ClinicalTrials.gov processed this record on November 27, 2009