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Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

This study has been completed.

Sponsored by: Universita di Verona
Information provided by: Universita di Verona
ClinicalTrials.gov Identifier: NCT00477789
  Purpose

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.


Condition Intervention Phase
Chronic Heart Failure
Drug: allopurinol
Phase IV

MedlinePlus related topics:   Heart Failure   

ChemIDplus related topics:   Allopurinol    Allopurinol sodium   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title:   Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Further study details as provided by Universita di Verona:

Primary Outcome Measures:
  • diastolic function uric acid levels BNP [ Time Frame: three months ]

  Eligibility
Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Inclusion Criteria:

  • chronic heart failure;
  • left ventricular systolic dysfunction (ejection fraction <45%)
  • stable clinical conditions in the previous three months
  • optimal medical therapy for CHF
  • normal sinus rhythm
  • written informed consent
  • age >18 years

Exclusion Criteria:

  • renal failure (s-creatinine >2.5 mg/dl)
  • already on allopurinol
  • malignancies
  • chronic inflammatory diseases
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00477789

Locations
Italy
Division of Cardiology, University Hospital of Verona    
      Verona, Italy, 37129

Sponsors and Collaborators
Universita di Verona

Investigators
Principal Investigator:     Mariantonietta Cicoira, MD, PhD     Division of Cardiology, University of Verona, Italy    
  More Information


Study ID Numbers:   802
First Received:   May 23, 2007
Last Updated:   May 23, 2007
ClinicalTrials.gov Identifier:   NCT00477789
Health Authority:   Italy: Ethics Committee

Keywords provided by Universita di Verona:
chronic heart failure  
diastolic dysfunction  
uric acid  

Study placed in the following topic categories:
Uric Acid
Allopurinol
Heart Failure
Heart Diseases

Additional relevant MeSH terms:
Antimetabolites
Antioxidants
Molecular Mechanisms of Pharmacological Action
Therapeutic Uses
Physiological Effects of Drugs
Free Radical Scavengers
Enzyme Inhibitors
Cardiovascular Diseases
Antirheumatic Agents
Protective Agents
Gout Suppressants
Pharmacologic Actions

ClinicalTrials.gov processed this record on October 10, 2008




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