Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients - Full Text View

Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

This study has been completed.

Sponsored by:	Universita di Verona
Information provided by:	Universita di Verona
ClinicalTrials.gov Identifier:	NCT00477789

Purpose

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Condition	Intervention	Phase
Chronic Heart Failure	Drug: allopurinol	Phase IV

MedlinePlus related topics:

Heart Failure

ChemIDplus related topics:

Allopurinol Allopurinol sodium

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study

Official Title:	Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Further study details as provided by Universita di Verona:

Primary Outcome Measures:

diastolic function uric acid levels BNP [ Time Frame: three months ]

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

chronic heart failure;
left ventricular systolic dysfunction (ejection fraction <45%)
stable clinical conditions in the previous three months
optimal medical therapy for CHF
normal sinus rhythm
written informed consent
age >18 years

Exclusion Criteria:

renal failure (s-creatinine >2.5 mg/dl)
already on allopurinol
malignancies
chronic inflammatory diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00477789

Locations


Italy
	Division of Cardiology, University Hospital of Verona
	Verona, Italy, 37129

Sponsors and Collaborators

Universita di Verona

Investigators


Principal Investigator:	Mariantonietta Cicoira, MD, PhD	Division of Cardiology, University of Verona, Italy

More Information

Study ID Numbers:	802
First Received:	May 23, 2007
Last Updated:	May 23, 2007
ClinicalTrials.gov Identifier:	NCT00477789
Health Authority:	Italy: Ethics Committee

Keywords provided by Universita di Verona:

chronic heart failure

diastolic dysfunction

uric acid

Study placed in the following topic categories:

Uric Acid

Allopurinol

Heart Failure

Heart Diseases

Additional relevant MeSH terms:

Antimetabolites

Antioxidants

Molecular Mechanisms of Pharmacological Action

Therapeutic Uses

Physiological Effects of Drugs

Free Radical Scavengers

Enzyme Inhibitors

Cardiovascular Diseases

Antirheumatic Agents

Protective Agents

Gout Suppressants

Pharmacologic Actions

ClinicalTrials.gov processed this record on October 10, 2008