Ambient Air Pollution, Preeclampsia, and Preterm Delivery
Recruitment status was Active, not recruiting
An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.
|Study Design:||Observational Model: Defined Population
Time Perspective: Longitudinal
|Official Title:||Ambient Air Pollution, Preeclampsia, and Preterm Delivery|
|Study Start Date:||July 2006|
We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy. We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.
|Principal Investigator:||Carole Rudra, Ph.D, MPH||Swedish Medical Center, First Hill|
|Principal Investigator:||Michelle A Williams, Sc.D||Swedish Medical Center|