Fluorine-18-α–Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer

This study has been completed.
Sponsor:
Information provided by:
Gunma University
ClinicalTrials.gov Identifier:
NCT00464282
First received: April 20, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted
  Purpose

Objective: L-[3-18F]-α–methyltyrosine (FMT) is an amino-acid tracer for PET. We evaluated the diagnostic usefulness of 18F-FMT PET in non-small cell lung cancer (NSCLC) patients. Tumor uptake of 18F-FMT PET was compared with 18F-FDG PET and the correlation with L-type amino acid transporter 1 (LAT1) expression also investigated.

Method: Fifty patients with NSCLC were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. LAT1 expression and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical study.


Condition
Carcinoma, Non-Small-Cell Lung

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal

Resource links provided by NLM:


Further study details as provided by Gunma University:

  Eligibility

Ages Eligible for Study:   8 Months to 2 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • proven or suspected non-small cell lung cancer

Exclusion Criteria:

  • uncontrolled diabetes mellitus
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00464282

Sponsors and Collaborators
Gunma University
Investigators
Principal Investigator: kyoichi kaira, MD Gunma Unversity Graduate School of Medicine
  More Information

No publications provided by Gunma University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00464282     History of Changes
Other Study ID Numbers: Gunma 444
Study First Received: April 20, 2007
Last Updated: April 20, 2007
Health Authority: Japan: Institutional Review Board

Keywords provided by Gunma University:
Fluorine–18-α–methyltyrosine,
Positron emission tomography,
Fluorodeoxyglucose
Lung cancer,
Amino acid transportor 1,
Ki-67
Proven or suspected non-small cell lung cancer were enrolled in the study

Additional relevant MeSH terms:
Carcinoma
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Carcinoma, Bronchogenic
Bronchial Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on July 20, 2014