The Role of Exercise and Diet in Weight Loss in Obese Children

This study has been completed.
Sponsor:
Collaborators:
D CURE- advancing diabetes care to cure.
Pediatric Endocrine unit, Soroka medical center.
Information provided by:
Rabin Medical Center
ClinicalTrials.gov Identifier:
NCT00461994
First received: April 17, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted
  Purpose

A 3-arms randomized prospective intervention study to determine the roles of exercise and/or diet on weight loss and weight maintenance in obese preadolescent children 6-11 year-old with BMI> 95th percentile for age and gender. Children were randomly allocated into three groups. The first group underwent an exercise program, the second one underwent both an exercise program and a diet program and the third underwent a diet program alone.

The total duration of the intervention is 12 weeks followed by a period of 9 months of follow-up. The effects of the different intervention on weight loss and weight maintenance,body composition, on hormonal components that regulate the caloric balance, on metabolic profile and cardiovascular risk factors and on psychological parameters were also determined.


Condition Intervention
Pediatric Obesity
Behavioral: diet
Behavioral: exercise
Behavioral: diet and exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The Role of Exercise and/or Diet in Weight Loss, and Weight Maintenance in Obese Preadolescent Children

Resource links provided by NLM:


Further study details as provided by Rabin Medical Center:

Primary Outcome Measures:
  • BMI
  • BMI-SDS
  • BODY FAT PERCENTAGE
  • WAIST AND HIP CIRCUMFERENCES

Secondary Outcome Measures:
  • BLOOD METABOLIC PROFILE
  • BLOOD INFLAMATORY MARKERS
  • GHRELIN AND LEPTIN LEVELS
  • RESTING ENERGY EXPENDITURE
  • PSYCHOLOGICAL PARAMETERS

Estimated Enrollment: 160
Study Start Date: April 2004
Study Completion Date: December 2006
Detailed Description:

A 3-arms randomized prospective intervention study including 161 patients in order to determine the roles of exercise and/or diet on weight loss and weight maintenance in obese preadolescent children 6-11 year-old with BMI> 95th percentile for age and gender. The study recruited patients from 2 endocrine clinics.

Objectives:

  1. The main aim was to determine the roles of exercise and/or diet on weight loss and weight maintenance in obese children.
  2. Secondary goals were:

    1. To determine the effects of exercise and/or diet on body composition.
    2. To determine the effects of exercise and/or diet on leptin and ghrelin that play a role in the regulation of energy balance.
    3. To determine the effects of exercise and/or diet on metabolic profile, cardiovascular risk factors, and inflammatory markers as fasting glucose,insulin and lipid profile,homocysteine ,adiponectin levels,CRP,and IL-6.
    4. To determine the role of exercise and/or diet on psychological parameters of obese children.

Study Population

Inclusion Criteria

  1. Obese preadolescent children 6-11 year-old with BMI> 95th percentile for age and gender.
  2. A signed informed consent will be taken from patients and their parents.
  3. Agreement to a follow-up of one year.

Exclusion Criteria

  1. Cardiac problems (arrhythmia, Congestive heart disease)
  2. Uncontrolled hypertension
  3. Severe hepatic impairment (liver enzymes above 3 folds the upper normal values)
  4. Renal failure
  5. Genetic syndromes associated with obesity
  6. Presence of untreated hypothyroidism
  7. Participation in a clinical study during the last month methods Children fulfilling the inclusion and exclusion criteria were randomly allocated into one of three groups.

The first group underwent an exercise program, the second one underwent both an exercise program and a diet program and the third underwent a diet program alone.

On the first visit of the study, at the end of the intervention (12 weeks) and at the end of the follow-up period (1 year) the following had been checked:

Weight, Height, Body impedance, Waist and hip circumferences, Skin-folds, Blood pressure, Basal Metabolic Rate (evaluated by a metabolic monitor), and blood samples for: Blood count, Liver function, Renal function, Fasting Lipid, glucose and insulin,CRP, IL-6, TSH, free T4, Homocysteine, Adiponectin, Leptin and Ghrelin. Also at these point of time every patient underwent a psychosocial evaluation with life style questioners.

Safety:There were no complications with these modes of treatment.

  Eligibility

Ages Eligible for Study:   6 Years to 11 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Obese preadolescent children 6-11 year-old with BMI> 95th percentile for age and gender.
  2. A signed informed consent will be taken from patients and their parents.
  3. Agreement to a follow-up of one year.

Exclusion Criteria:

  1. Cardiac problems (arrhythmia, Congestive heart disease)
  2. Uncontrolled hypertension
  3. Severe hepatic impairment (liver enzymes above 3 folds the upper normal values)
  4. Renal failure
  5. Genetic syndromes associated with obesity
  6. Presence of untreated hypothyroidism
  7. Participation in a clinical study during the last month
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00461994

Locations
Israel
Soroka Medical Center
Beer-Sheva, Israel
Schneider Children's Medical Center
Petah-Tikva, Israel, 49202
Sponsors and Collaborators
Rabin Medical Center
D CURE- advancing diabetes care to cure.
Pediatric Endocrine unit, Soroka medical center.
Investigators
Principal Investigator: Moshe Phillip, Prof, MD Schneider Children Medical Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00461994     History of Changes
Other Study ID Numbers: rmc003189CTil
Study First Received: April 17, 2007
Last Updated: April 17, 2007
Health Authority: Israel: Ministry of Health

Keywords provided by Rabin Medical Center:
OBESITY
CHILDREN
METABOLIC PARAMETERS
DIET
EXERCISE

Additional relevant MeSH terms:
Obesity
Weight Loss
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Body Weight Changes

ClinicalTrials.gov processed this record on July 24, 2014