ADMA and Mechanical Ventilation in Preterm Infants

This study has been completed.
Sponsor:
Information provided by:
VU University Medical Center
ClinicalTrials.gov Identifier:
NCT00460044
First received: April 11, 2007
Last updated: April 12, 2007
Last verified: April 2007
  Purpose

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.


Condition
Premature Birth

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants

Further study details as provided by VU University Medical Center:

Estimated Enrollment: 35
Study Start Date: January 2002
Study Completion Date: July 2003
Detailed Description:

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

  Eligibility

Ages Eligible for Study:   up to 32 Weeks
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Gestational age < 32 weeks
  • Birth weight < 1500 gram
  • Written informed consent of parents

Exclusion Criteria:

  • Congenital abnormalities
  • Chromosomal abnormalities
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00460044

Sponsors and Collaborators
VU University Medical Center
Investigators
Study Director: R M van Elburg, MD, PhD VU University Medical Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00460044     History of Changes
Other Study ID Numbers: HK0607
Study First Received: April 11, 2007
Last Updated: April 12, 2007
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by VU University Medical Center:
ADMA
Preterms
infants
mechanical ventilation
Preterm infants

Additional relevant MeSH terms:
Premature Birth
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications

ClinicalTrials.gov processed this record on September 18, 2014