Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma
Recruitment status was Active, not recruiting
Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma|
- Decrease in oral steroid therapy requirements.
- improvement in symptoms scores
- improvement in spirometric outcomes
- improvement in morning and evening peak flow
- decrease in rescue inhaler usage
|Study Start Date:||June 1996|
|Estimated Study Completion Date:||October 2007|
This is a double-blind, placebo-controlled crossover study of adult asthmatics given minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are recorded. A standardized asthma quality of life symptoms assessment is made every four weeks (AQLQ, Juniper).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00456677
|United States, New York|
|SUNY Downstate Medical Center|
|Brooklyn, New York, United States, 11203|
|Principal Investigator:||Rauno Joks, MD||State University of New York - Downstate Medical Center|