Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children (ALTAC)
Recruitment status was Not yet recruiting
Study based in Southern Ethiopia Purpose - to explore if children in contact with adults with TB have positive acute reactants such as IFN-y and other cytokine responses; if these responses discriminate between high and low risk of disease progression and whether these could be incorporated into improved diagnostic approaches.
|Study Design:||Observational Model: Defined Population
Time Perspective: Longitudinal
|Official Title:||Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children|
|Study Start Date:||May 2007|
|Estimated Study Completion Date:||October 2009|
The study follows children in contact with TB. Those with positive TST will be offered chemoprophylaxis and all children will be followed for 2 years to describe IFN-y responses over time, identify symptoms of active TB and if these symptoms are associated with IFN-y and other cytokine responses.
Children with suspicion of TB attending health centres will also be investigated using routine diagnostic tests and IFN-y and other cytokines responses to evaluate if the latter could be used in improved diagnostic approaches.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00456469
|Contact: Luis Cuevas, MD MTropMed||0151 705 firstname.lastname@example.org|
|Bushullo Major Health Centre||Not yet recruiting|
|Awassa, Southern Region, Ethiopia, 12|
|Contact: Mohammed Yassin, Dr|
|Sub-Investigator: Mohammed Yassin, Dr|
|Principal Investigator:||Luis Cuevas, Dr||Liverpool School of Tropical Medicine|