Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Carlos A. Camargo, Brigham and Women's Hospital
ClinicalTrials.gov Identifier:
NCT00454415
First received: March 28, 2007
Last updated: December 24, 2012
Last verified: December 2012
  Purpose

Asthma is a common illness among children in the United States. While there are many known causes of asthma, including tobacco smoke, pollen, dust, or other allergens, the exact cause of asthma in some individuals remains unknown. This study will examine the role that specific dietary factors and body mass index (BMI) play in the development of childhood asthma.


Condition
Asthma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children

Resource links provided by NLM:


Further study details as provided by Brigham and Women's Hospital:

Primary Outcome Measures:
  • incident asthma [ Time Frame: childhood ] [ Designated as safety issue: No ]

Enrollment: 16000
Study Start Date: January 2007
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Detailed Description:

Asthma prevalence has steadily increased in the United States since the early 1980s, but the exact cause of this increase remains unknown. It is estimated that at least 8% of Americans have asthma. Although anti-inflammatory medications have proven effective for decreasing asthma exacerbations, there are few treatment options available to prevent the initial onset of the disease. Dietary factors and BMI may play a role in the development of asthma. Specifically, individuals who eat foods containing antioxidants (e.g., vitamin C, vitamin E, and carotenoids), n-3 polyunsaturated fatty acids (e.g., fish oils), and vitamin D may have a decreased risk of developing asthma, while individuals with higher BMI ratios may have an increased asthma risk. The purpose of this study is to evaluate the relationship among dietary factors, BMI, and the incidence of asthma among children.

This study will enroll children participating in the Growing Up Today study and children of nurses who are participating in the Nurses Health Study II. Researchers will analyze participants' previously completed questionnaires on dietary intake, physical activity, height, weight, and the presence of physician-diagnosed asthma. All participants with physician-diagnosed asthma will receive an additional asthma questionnaire. A small portion of these participants will also have their medical records reviewed by study researchers, and mothers of these children will be asked to complete a questionnaire. Additionally, a questionnaire will be sent to and completed by children who do not have asthma and their mothers.

  Eligibility

Ages Eligible for Study:   9 Years to 14 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

U.S. children

Criteria

Inclusion Criteria:

  • Children of women in the Nurses Health Study II (NHS2)
  • Participated in the Growing Up Today study

Exclusion Criteria:

  • None
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00454415

Locations
United States, Massachusetts
Channing Laboratory, Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Brigham and Women's Hospital
Investigators
Principal Investigator: Carlos A. Camargo, MD, DrPH Channing Laboratory, Brigham and Women's Hospital
  More Information

No publications provided

Responsible Party: Carlos A. Camargo, Professor of Medicine, Brigham and Women's Hospital
ClinicalTrials.gov Identifier: NCT00454415     History of Changes
Other Study ID Numbers: 1376, R01HL084401-01A1, R01 HL084401-01A1
Study First Received: March 28, 2007
Last Updated: December 24, 2012
Health Authority: United States: Federal Government

Keywords provided by Brigham and Women's Hospital:
Diet
Body Mass Index
BMI

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on July 20, 2014