Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study

This study has been completed.
Sponsor:
Information provided by:
National University Hospital, Singapore
ClinicalTrials.gov Identifier:
NCT00452998
First received: March 27, 2007
Last updated: May 12, 2008
Last verified: May 2008
  Purpose

Sequential Laser Iridotomy uses argon and Nd:yag laser in the first and second steps, respectively. Using q-switched 532 nm laser in the second step is hypothesized to be as good and effective as the conventional Nd:yag laser, because it selectively targets pigmented cells and delivers a short pulse duration of 3 nanoseconds, causing less thermal and collateral damage.


Condition Intervention
Chronic Angle Closure Glaucoma
Primary Angle Closure
Primary Angle Closure Suspect
Fellow Eyes of Acute Angle Closure Glaucoma
Procedure: Q-switched fd Nd:yag in Laser Iridotomy

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study

Resource links provided by NLM:


Further study details as provided by National University Hospital, Singapore:

Primary Outcome Measures:
  • Visual Acuity
  • Intraocular pressure
  • Total power delivered by each laser modality
  • Iridotomy patency and size
  • Pain rating during the procedure
  • Anterior segment inflammation
  • Endothelial cell count
  • Cataract progression
  • Rate of complications

Estimated Enrollment: 10
Study Start Date: November 2006
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   22 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • More than 21 years old
  • Able to give informed consent
  • Diagnosis of either: chronic angle closure glaucoma (CACG), primary angle closure (PAC), primary angle closure suspect (PACS) or fellow eyes of acute angle closure glaucoma (AACG), and in need of a laser iridotomy

Exclusion Criteria:

  • History of any prior laser treatment or intraocular surgery to the eye
  • History of any corneal disease
  • Any ocular infection/ inflammation within the last two months
  • Inability to give informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00452998

Locations
Singapore
National University Hospital
Singapore, Singapore, 119074
Sponsors and Collaborators
National University Hospital, Singapore
Investigators
Principal Investigator: Paul Chew, FRCSEd,MMed National University Hospital, Singapore
  More Information

Publications:
Responsible Party: Cecilia Aquino, MD, National University Hospital, Singapore
ClinicalTrials.gov Identifier: NCT00452998     History of Changes
Other Study ID Numbers: DSRB A/06/293
Study First Received: March 27, 2007
Last Updated: May 12, 2008
Health Authority: Singapore: Health Sciences Authority

Keywords provided by National University Hospital, Singapore:
Sequential Laser Iridotomy
Q-Switched 532 nm Laser
Frequency Doubled Neodymium Yag Laser

Additional relevant MeSH terms:
Acute Disease
Glaucoma
Glaucoma, Angle-Closure
Disease Attributes
Eye Diseases
Ocular Hypertension
Pathologic Processes

ClinicalTrials.gov processed this record on October 30, 2014