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| Sponsor: | Viborg Hospital |
|---|---|
| Collaborator: |
Nielsen, Jens OD, M.D. |
| Information provided by: | Viborg Hospital |
| ClinicalTrials.gov Identifier: | NCT00452855 |
Purpose
The purpose of this study is to determine whether sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia concerning post- operative nausea and vomiting.
| Condition | Intervention |
|---|---|
|
Nausea Vomiting |
Procedure: Sevoflurane-remifentanil anaesthesia |
| Study Type: | Interventional |
| Study Design: | Prevention, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study |
| Official Title: | Postoperative Nausea and Vomiting Are Similar When Propofol or Sevoflurane Are Used as Adjuvant to Remifentanil During Anaesthesia for Gynaecological Surgery |
| Estimated Enrollment: | 160 |
| Study Start Date: | January 2002 |
| Study Completion Date: | May 2005 |
Propofol and sevoflurane anaesthesia are used world wide at the anaesthetists discretion.
Propofol is superior to inhalational anaesthetics as anaesthesia for patients at risk of post operative nausea and vomiting (PONV) as PONV is diminished. However, when remifentanil is used as adjuvant to sevoflurane, the total dose of the latter is reduced.
Therefore, we wanted to investigate if sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia with emphasis on nausea, vomiting and total PONV during 24 hours.
In the post anaesthesia care unit (PACU) and in the surgical ward nausea was scored on a visual analogue score. Vomiting was registered.
Eligibility| Ages Eligible for Study: | 18 Years to 50 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations
More Information
| Study ID Numbers: | PropSevoRemi |
| Study First Received: | March 26, 2007 |
| Last Updated: | March 28, 2007 |
| ClinicalTrials.gov Identifier: | NCT00452855 History of Changes |
| Health Authority: | Denmark: Ethics Committee |
|
Nausea Vomiting Post operative Propofol remifentanil anaesthesia Sevoflurane remifentanil anaesthesia |
|
Vomiting Signs and Symptoms, Digestive Physiological Effects of Drugs Hematologic Agents Anesthetics Sevoflurane Signs and Symptoms Pathologic Processes Sensory System Agents Therapeutic Uses Hypnotics and Sedatives Nausea Analgesics |
Analgesics, Opioid Anesthetics, Intravenous Postoperative Nausea and Vomiting Remifentanil Central Nervous System Depressants Pharmacologic Actions Anesthetics, Inhalation Postoperative Complications Anesthetics, General Platelet Aggregation Inhibitors Peripheral Nervous System Agents Central Nervous System Agents |