The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2013 by National Heart, Lung, and Blood Institute (NHLBI)
Sponsor:
Collaborator:
University of California, San Francisco
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00451919
First received: March 23, 2007
Last updated: October 29, 2013
Last verified: October 2013
  Purpose

Sickle cell disease is an inherited blood disorder that affects red blood cells (RBCs). People with sickle cell disease frequently experience anemia, or a low number of RBCs. RBCs are responsible for carrying oxygen to the brain and other body tissues that need oxygen to function properly. The purpose of this study is to determine what changes, which were possibly caused by anemia, exist in the brains of individuals with sickle cell disease.


Condition
Sickle Cell Disease

Study Type: Observational
Official Title: Sickle-Cell Disease: Neuroimaging and Cognitive Decline

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Estimated Enrollment: 120
Study Start Date: July 2006
Detailed Description:

The role of RBCs is to carry oxygen from the lungs to the brain and other body tissues. Individuals with anemia have unusually low numbers of RBCs. They also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. Previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. The purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities.

Participants will attend one study visit. During this visit, a brain magnetic resonance image (MRI) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. There will be no follow-up visits.

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Diagnosis of sickle cell disease

Exclusion Criteria:

  • Pregnancy
  • Claustrophobia
  • Mass lesion (e.g., meningioma, cyst, or spinal block)
  • Need for life support constant monitoring
  • Any unstable condition that is likely to require resuscitation
  • Presence of a pacemaker or other iron-containing magnetic substances in the body
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00451919

Contacts
Contact: Randall R. Rule, PhD 415-221-4810 ext 4830 randall.rule@ucsf.edu
Contact: Jeffrey Kasten 415-221-4810 ext 2030 jeffrey.kasten@ucsf.edu

Locations
United States, California
University of California San Francisco Recruiting
San Francisco, California, United States, 94121
Contact: Randall R. Rule, PhD    415-221-4810 ext 4830    randall.rule@ucsf.edu   
Contact: Jeffrey Kasten    415-221-4810 ext 2030    jeffrey.kasten@ucsf.edu   
Principal Investigator: Randall R. Rule, PhD         
Sponsors and Collaborators
University of California, San Francisco
Investigators
Principal Investigator: Randall R. Rule, PhD University of California, San Francisco
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00451919     History of Changes
Other Study ID Numbers: 375, K01 HL073152
Study First Received: March 23, 2007
Last Updated: October 29, 2013
Health Authority: United States: Federal Government

Keywords provided by National Heart, Lung, and Blood Institute (NHLBI):
MRI
Neuropsychology

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on September 30, 2014