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Multidrug Resistance After Trabeculectomy With Mitomycin C

This study has been completed.
Sponsor:
Information provided by:
University of Cologne
ClinicalTrials.gov Identifier:
NCT00449631
First received: March 19, 2007
Last updated: March 23, 2007
Last verified: March 2007
  Purpose

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.


Condition
Glaucoma
Trabeculectomy

Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Multidrug Resistance After Trabeculectomy With Mitomycin C

Resource links provided by NLM:


Further study details as provided by University of Cologne:

Estimated Enrollment: 30
Detailed Description:

Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

  Eligibility

Ages Eligible for Study:   8 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients with planned trabeculectomy for elevated eye pressure
  • one third of patients without previous trabeculectomy
  • two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion Criteria:

  • patients not requiring surgery
  • patients with planned surgery for elevated eye pressure other than trabeculectomy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00449631

Locations
Germany
The University Hospital of Cologne
Cologne, Germany, 50924
Sponsors and Collaborators
University of Cologne
Investigators
Principal Investigator: Arno Hueber, MD University of Cologne
  More Information

No publications provided by University of Cologne

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00449631     History of Changes
Other Study ID Numbers: Multidrug Resistance
Study First Received: March 19, 2007
Last Updated: March 23, 2007
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by University of Cologne:
Glaucoma
Drug Resistance, Multiple
Trabeculectomy

Additional relevant MeSH terms:
Glaucoma
Eye Diseases
Ocular Hypertension

ClinicalTrials.gov processed this record on November 20, 2014