Magnetic Resonance Imaging of Brain Development in Autism

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2007 by UMC Utrecht.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
UMC Utrecht
ClinicalTrials.gov Identifier:
NCT00449566
First received: March 18, 2007
Last updated: NA
Last verified: March 2007
History: No changes posted
  Purpose

The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.


Condition
Autism

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Longitudinal
Official Title: Magnetic Resonance Imaging of Brain Development in Autism

Resource links provided by NLM:


Further study details as provided by UMC Utrecht:

Estimated Enrollment: 300
Study Start Date: January 2006
  Eligibility

Ages Eligible for Study:   6 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Aged 6 - 18 years at initial MRI

Inclusion criteria for subjects with autism

1) DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview

Inclusion criteria for controls

  1. no DSM-IV (APA, 1994) diagnosis, according to DISC interview
  2. no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
  3. IQ > 70

Exclusion Criteria:

  1. major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  2. presence of metal objects in or around the body (pacemaker, dental braces)
  3. history of or present neurological disorder
  4. for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00449566

Contacts
Contact: Sarah Durston +31 30 250 8161 S.Durston@umcutrecht.nl

Locations
Netherlands
Dept. of Child and Adolescent Psychiatry, UMC Utrecht Recruiting
Utrecht, Netherlands, 3584CX
Contact: Marieke Langen, M.Sc.    +31 30 250 7084    M.Langen@umcutrecht.nl   
Principal Investigator: Marieke Langen, M.Sc.         
Principal Investigator: Hilde Nederveen, M.Sc.         
Sponsors and Collaborators
UMC Utrecht
Investigators
Principal Investigator: Sarah Durston, Ph.D. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
Study Chair: Herman van Engeland, M.D. Ph.D. Rudolf Magnust Institute of Neuroscience, UMC Utrecht
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT00449566     History of Changes
Other Study ID Numbers: METC 05/208-K
Study First Received: March 18, 2007
Last Updated: March 18, 2007
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by UMC Utrecht:
Magnetic Resonance Imaging
Diffusion Tensor Imaging

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Mental Disorders
Mental Disorders Diagnosed in Childhood

ClinicalTrials.gov processed this record on October 23, 2014