Effect of Conjugated Linoleic Acid Intake on Liver and Kidney Function
The knowledge of the health effects of CLA on the human body is limited. However, CLA supplements are sold over the counter in several countries and various techniques are used to increase the content of CLA in food.
The CLAxon-study will be performed to investigate wether high doses of CLA can be safely given to healthy human volunteers.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:||The Effect of Conjugated Linoleic Acid Intake on Liver and Kidney Function in Healthy Volunteers (CLAxon-Study)|
- alkaline phosphatase
- lactate dehydrogenase
- creatinine clearance
- total cholesterol
- HDL cholesterol
- LDL cholesterol
- fatty acids
|Study Start Date:||March 2007|
|Study Completion Date:||June 2007|
Each volunteer receives CLA enriched products for a total of 3 weeks containing approximately 20g CLA per day. A control group is not needed. If three subjects or more show one or more blood values for liver and kidney function above predefined limits the study will be terminated.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00449462
|VU University Amsterdam, Institute for Health Sciences|
|Wageningen University, Division of Human Nutrition|
|Principal Investigator:||Ingeborg A Brouwer, PhD||VU University of Amsterdam|
|Principal Investigator:||Martijn B Katan, Professor||VU University of Amsterdam|