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Study of the Natural Variation in Strokevolume

This study has been completed.
Sponsor:
Information provided by:
Rigshospitalet, Denmark
ClinicalTrials.gov Identifier:
NCT00447200
First received: March 13, 2007
Last updated: October 12, 2007
Last verified: October 2007
History of Changes
  Purpose

We would like to investigate the natural variation in the strokevolume of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in strokevolume, after a fluid bolus of 200ml Voluven, when using Esophageal Doppler.


Condition Intervention
Stroke Volume Variation
 Procedure: Esophagus Doppler monitoring
Procedure: Fluid optimization

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Study of the Natural Variation in Strokevolume, and Investigation in the Number of Cycles Necessary to Find a 10% Strokevolume Variation Using Esophageal Doppler

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Rigshospitalet, Denmark:

Primary Outcome Measures:
  • Strokevolume variation before fluid optimization
  • Strokevolume variation after fluid optimization
  • Number of cycles needed in order to detect a 10% strokevolume increase after fluid bolus of 200ml Voluven.

Enrollment: 20
Study Start Date: March 2007
Study Completion Date: August 2007
Detailed Description:

We would like to investigate the natural variation in the strokevolume(SV) of the heart. At the same time we would like to find out the minimal number of heart cycles necessary to discover a 10% increase in SV, after a fluid bolus of 200ml Voluven, when using Esophageal Doppler.

Also we will compare the variation in SV both before and after the patients have been fluid optimized, using an algorithm of 10% increase in SV in order to receive another fluid bolus. The equipment used, will be the CardioQ from Deltex medical.

  Eligibility

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Planned abdominal surgery

Exclusion Criteria:

  • Oesophageal pathology,
  • Age >90 yr or <18 yr,
  • Alcohol abuse,
  • Aneurism in thoracic aorta
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00447200

Locations
Denmark
Rigshospitalet
Copenhagen, Seeland, Denmark, 2200
Sponsors and Collaborators
Rigshospitalet, Denmark
Investigators
Principal Investigator: Christoffer Jorgensen, M.S Dept of anesthesia 2041, ABD centre, Rigshospitalet, Blegdamsvej
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00447200     History of Changes
Other Study ID Numbers: Validation of cycles
Study First Received: March 13, 2007
Last Updated: October 12, 2007
Health Authority: Denmark: National Board of Health

Keywords provided by Rigshospitalet, Denmark:
Stroke volume
SV variation
Esophagus Doppler
Goal Directed Therapy

Additional relevant MeSH terms:
Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
 Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 19, 2013