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Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2007 by Melbourne Health.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Melbourne Health
ClinicalTrials.gov Identifier:
NCT00446212
First received: March 8, 2007
Last updated: NA
Last verified: March 2007
History: No changes posted
  Purpose

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.


Condition Intervention Phase
Anaesthesia
Dreaming
 Drug: Propofol
Drug: desflurane
 Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic
Official Title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Melbourne Health:

Primary Outcome Measures:
  • Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire

Estimated Enrollment: 300
Study Start Date: August 2006
Estimated Study Completion Date: August 2007
Detailed Description:

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male and female patients
  • Age between 18 and 50 years
  • Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

  • Inadequate English language comprehension
  • Major drug abuse problem
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00446212

Contacts
Contact: Kate Leslie, MD 61-3-93427000 kate.leslie@mh.org.au

Locations
Australia, Victoria
Royal Melbourne Hospital Recruiting
Parkville, Victoria, Australia, 3050
Contact: Kate Leslie, MD     61-3-93427000     kate.leslie@mh.org.au    
Principal Investigator: Kate Leslie, MD            
Australia, Western Australia
Royal Perth Hospital Recruiting
Perth, Western Australia, Australia, 6000
Contact: Michael Paech, MD     61-8-9340 2222     michael. paech@health.wa.gov.au    
Principal Investigator: Michael Paech, MD            
King Edward Memorial Hospital for Women Recruiting
Subiaco, Western Australia, Australia, 6008
Contact: Michael Paech, MD     61-8-9340 2222     michael.paech@health.wa.gov.au    
Principal Investigator: Michael Paech, MD            
New Zealand
Waikato Hospital Recruiting
Hamilton, New Zealand
Contact: Jamie Sleigh, MD     64-7-8398899     sleighj@waikatodhb.govt.nz    
Principal Investigator: Michael Paech, MD            
Sponsors and Collaborators
Melbourne Health
Investigators
Principal Investigator: Kate Leslie, MD Melbourne Health
  More Information

No publications provided by Melbourne Health

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

ClinicalTrials.gov Identifier: NCT00446212     History of Changes
Other Study ID Numbers: 2006.125
Study First Received: March 8, 2007
Last Updated: March 8, 2007
Health Authority: Australia: Department of Health and Ageing Therapeutic Goods Administration

Keywords provided by Melbourne Health:
anaesthesia
propofol
desflurane
dreaming
electroencephalography

Additional relevant MeSH terms:
Anesthetics
Propofol
Desflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
 Central Nervous System Agents
Therapeutic Uses
Anesthetics, Intravenous
Anesthetics, General
Hypnotics and Sedatives
Anesthetics, Inhalation

ClinicalTrials.gov processed this record on May 22, 2013