Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Recruitment status was Recruiting
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Purpose
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.
| Condition | Intervention | Phase |
|---|---|---|
|
Anaesthesia Dreaming |
Drug: Propofol Drug: desflurane |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Diagnostic |
| Official Title: | Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane |
- Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
| Estimated Enrollment: | 300 |
| Study Start Date: | August 2006 |
| Estimated Study Completion Date: | August 2007 |
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.
Eligibility| Ages Eligible for Study: | 18 Years to 50 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Male and female patients
- Age between 18 and 50 years
- Presenting for elective surgery under general anaesthesia
Exclusion Criteria:
- Inadequate English language comprehension
- Major drug abuse problem
Contacts and Locations| Contact: Kate Leslie, MD | 61-3-93427000 | kate.leslie@mh.org.au |
| Australia, Victoria | |
| Royal Melbourne Hospital | Recruiting |
| Parkville, Victoria, Australia, 3050 | |
| Contact: Kate Leslie, MD 61-3-93427000 kate.leslie@mh.org.au | |
| Principal Investigator: Kate Leslie, MD | |
| Australia, Western Australia | |
| Royal Perth Hospital | Recruiting |
| Perth, Western Australia, Australia, 6000 | |
| Contact: Michael Paech, MD 61-8-9340 2222 michael. paech@health.wa.gov.au | |
| Principal Investigator: Michael Paech, MD | |
| King Edward Memorial Hospital for Women | Recruiting |
| Subiaco, Western Australia, Australia, 6008 | |
| Contact: Michael Paech, MD 61-8-9340 2222 michael.paech@health.wa.gov.au | |
| Principal Investigator: Michael Paech, MD | |
| New Zealand | |
| Waikato Hospital | Recruiting |
| Hamilton, New Zealand | |
| Contact: Jamie Sleigh, MD 64-7-8398899 sleighj@waikatodhb.govt.nz | |
| Principal Investigator: Michael Paech, MD | |
| Principal Investigator: | Kate Leslie, MD | Melbourne Health |
More Information
No publications provided by Melbourne Health
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| ClinicalTrials.gov Identifier: | NCT00446212 History of Changes |
| Other Study ID Numbers: | 2006.125 |
| Study First Received: | March 8, 2007 |
| Last Updated: | March 8, 2007 |
| Health Authority: | Australia: Department of Health and Ageing Therapeutic Goods Administration |
Keywords provided by Melbourne Health:
|
anaesthesia propofol desflurane dreaming electroencephalography |
Additional relevant MeSH terms:
|
Anesthetics Propofol Desflurane Central Nervous System Depressants Physiological Effects of Drugs Pharmacologic Actions |
Central Nervous System Agents Therapeutic Uses Anesthetics, Intravenous Anesthetics, General Hypnotics and Sedatives Anesthetics, Inhalation |
ClinicalTrials.gov processed this record on May 22, 2013