Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane - Tabular View

Tracking Information

First Received Date ^ICMJE

March 8, 2007

Last Updated Date

March 8, 2007

Start Date ^ICMJE

August 2006

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire

Original Primary Outcome Measures ^ICMJE

Same as current

Change History

No Changes Posted

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Official Title ^ICMJE

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Brief Summary

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Detailed Description

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Study Phase

Phase IV

Study Type ^ICMJE

Interventional

Study Design ^ICMJE

Diagnostic, Randomized, Double-Blind, Active Control, Parallel Assignment, Pharmacodynamics Study

Condition ^ICMJE

Anaesthesia
Dreaming

Intervention ^ICMJE

Drug: Propofol
Drug: desflurane

Study Arms / Comparison Groups

Publications *

Leslie K, Sleigh J, Paech MJ, Voss L, Lim CW, Sleigh C. Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane. Anesthesiology. 2009 Sep;111(3):547-55.

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Recruiting

Enrollment ^ICMJE

300

Completion Date

August 2007

Primary Completion Date

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Male and female patients
Age between 18 and 50 years
Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

Inadequate English language comprehension
Major drug abuse problem

Gender

Both

Ages

18 Years to 50 Years

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact: Kate Leslie, MD

61-3-93427000

kate.leslie@mh.org.au

Location Countries ^ICMJE

Australia, New Zealand

Administrative Information

NCT ID ^ICMJE

NCT00446212

Responsible Party

Study ID Numbers ^ICMJE

2006.125

Study Sponsor ^ICMJE

Melbourne Health

Collaborators ^ICMJE

Investigators ^ICMJE

Principal Investigator:

Kate Leslie, MD

Melbourne Health

Information Provided By

Melbourne Health

Verification Date

March 2007

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP