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Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

This study has been completed.
Sponsor:
Information provided by:
Mayo Clinic
ClinicalTrials.gov Identifier:
NCT00443716
First received: March 5, 2007
Last updated: January 14, 2010
Last verified: January 2010
History of Changes
  Purpose

To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens collected from subjects recruited in the study (IRB number 21B85). The adipocytic parameters will be then correlated with osteoblastic parameters obtained previously during the course of the initai study involving the effect of transdermal estrogen on bone turnover in postmenopausal osteoporotic women.


Condition Intervention
Osteoporosis
Postmenopausal
 Drug: estrogen

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • efficacy of estraderm treatment on osteoporotic women

Estimated Enrollment: 60
Study Start Date: April 1985
Study Completion Date: April 1989
Primary Completion Date: April 1989 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   30 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Post-menopausal osteoporotic women

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00443716

Locations
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: B. Lawrence Riggs, M.D. Mayo Clinic
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00443716     History of Changes
Other Study ID Numbers: 05-004111, 21b85
Study First Received: March 5, 2007
Last Updated: January 14, 2010
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Osteoporosis
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Estrogens
 Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on May 23, 2013