D3-Growth Hormone Receptor Polymorphism and Total Effect of Recombinant Human Growth Hormone on Growth in Girls With Turner Syndrome
The protein polymorphism of the growth hormone receptor characterized by the genomic deletion of exon 3 has been linked to the magnitude of the first-year-growth response to growth hormone (GH) in girls with Turner syndrome.
Objective: to study the long-term effect of GH therapy in Turner syndrome in correlation to this GHR polymorphism in a mainly retrospective design (chart-review).
|Study Design:||Observational Model: Defined Population
Time Perspective: Longitudinal
|Tübingen, Germany, 72076|
|Principal Investigator:||Gerhard Binder, M.D. PhD||University-Children's Hospital Tübingen|