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Vasoactive Hormones and Oxygen Saturation During Apneic Events in Patients With Obstructive Sleep Apnea

This study has suspended participant recruitment.
(It was not possible to recruit enough patients with obstructive sleep apnea.)
Sponsor:
Information provided by:
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00438412
First received: February 20, 2007
Last updated: April 17, 2008
Last verified: April 2008
History of Changes
  Purpose

The mechanisms involved in development and maintenance of hypertension in obstructive sleep apnea are not clarified.

We hypothesize that patients with obstructive sleep apnea have an abnormal level of some vasoactive hormones during apneic events during sleep.


Condition Phase
Obstructive Sleep Apnea
 Phase 4

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Regional Hospital Holstebro:

Estimated Enrollment: 40
Study Start Date: October 2006
  Eligibility

Ages Eligible for Study:   20 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Adults, males and females,age 30 -65

Criteria

Patients with Obstructive sleep apnea

Inclusion Criteria:

  • Severe obstructive sleep apnea (apnea-hypopnea index > 30)

Exclusion Criteria:

  • Drug or alcohol abuse
  • Pregnancy
  • History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
  • Diabetes

Healthy Controls

Inclusion Criteria:

  • Apnea-hypopnea index < 10

Exclusion criteria:

  • Drug or alcohol abuse
  • Pregnancy
  • History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
  • Diabetes
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00438412

Locations
Denmark
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500
Sponsors and Collaborators
Regional Hospital Holstebro
Investigators
Study Chair: Erling B Pedersen, Professor Regional Hospital Holstebro
  More Information

No publications provided

Responsible Party: Pia Holland Gjørup, Department of Medical Research
ClinicalTrials.gov Identifier: NCT00438412     History of Changes
Other Study ID Numbers: MED.RES.HOS.2006.01.PHH
Study First Received: February 20, 2007
Last Updated: April 17, 2008
Health Authority: Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by Regional Hospital Holstebro:
Noradrenalin
Endothelin-1
Angiotensin II
Arginine vasopressin
Aldosterone
 Renin
Atrial natriuretic peptide
Brain natriuretic peptide
Blood pressure
Apnea

Additional relevant MeSH terms:
Apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Dyssomnias
 Sleep Disorders
Nervous System Diseases
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on May 19, 2013