Evaluating How the Nervous System Coordinates Voluntary Movement in the Arm
The purpose of this study is to investigate how the nervous system interprets joint position and movement. This will contribute to a broader knowledge of understanding how the human central nervous system (CNS), which includes the brain and spinal cord, coordinates voluntary movement.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Spatial and Temporal Control of Targeted Limb Movements|
- Afferent nerve-firing patterns [ Time Frame: At the time of the experimental session ] [ Designated as safety issue: No ]Nerve firing patterns are described as the sequence of time intervals between action potentials recorded from the nerve.
- Task performance levels [ Time Frame: At the time of the experimental session ] [ Designated as safety issue: No ]Task performance most often refers to the accuracy and/or precision of limb movement or of the accuracy and/or precision of detection of a somatosensory stimulus.
|Study Start Date:||January 1983|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Device: Manipulandum table
In motor nervous system disorders, such as stroke, the CNS is unable to coordinate normal voluntary movement. This is often caused by malfunctioning proprioception. Proprioception is one's sense of the relative position of neighboring body parts. It allows an individual to feel the orientation of one body part to another. It also provides information about the rate and direction of movement so that an individual can change muscle contraction immediately as incoming information about external forces is received. The two main components of proprioception include sensory nerve cells located in the inner ear and stretch receptors located in muscles, skin, tendons, and joint-supporting ligaments. The purpose of this study is to determine how proprioception is communicated from the stretch receptors in skin, joints, and muscles to the CNS. Specifically, the study will compare the differing roles of agonists, muscles that cause movement, versus antagonists, muscles that oppose agonists, in proprioception.
Participants will be assigned to one of seven substudy groups. Each group will partake in one or more study experiments, which will each take 1 to 4 hours. Participants enrolled in more than one experiment will report to the study site on separate days. For each experiment, the participant will sit at a table with a specialized device, called a manipulandum, which has motorized elbow, wrist, and finger manipulators to control the movement and position of a participant's arm. Depending on the experiment, several forms of joint rotation and arm movement will be carried out by either the participant or the manipulandum. Electrical activity of certain muscles and nerves will be recorded in all experiments by various kinds of electrodes. A tendon vibrator will be used in some experiments to activate muscle receptors that signal to what extent and how fast a muscle is contracting or stretching. Regional anesthesia will also be used in some experiments to reduce sensory input from the skin and joints. Participants will receive follow-up phone calls after an experiment to check for any side effects from procedures.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00437515
|United States, Oregon|
|Oregon Health and Science University|
|Portland, Oregon, United States, 97239-3098|
|Principal Investigator:||Paul Cordo, PhD||Oregon Health and Science University|