Frequency of ICAM-1 Polymorphisms in Obese Subjects - Full Text View

Sponsor:	Istituto Auxologico Italiano
Information provided by:	Istituto Auxologico Italiano
ClinicalTrials.gov Identifier:	NCT00436488

Purpose

The genetic contribution to the development of obesity is now well recognized. However obesity is a polygenic disease and thus many genes are likely to be involved. This study aims to investigate the possible association between specific variants of the gene coding for the Intercellular Adhesion Molecule-1 (ICAM-1)and the development of severe obesity in an Italian population

Condition
Obesity

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study
Official Title:	Study of the Association Between ICAM-1 Polymorphisms and Severe Obesity

Resource links provided by NLM:

Genetics Home Reference related topics: Help Me Understand Genetics

MedlinePlus related topics: Obesity

U.S. FDA Resources

Further study details as provided by Istituto Auxologico Italiano:

Estimated Enrollment:	200
Study Start Date:	January 2005
Estimated Study Completion Date:	July 2006

Detailed Description:

Severely obese subjects referred to our institution will be evaluated. For the aim of the study, a venous blood sample will be obtained from these subjects and from a group of normal weight volunteers. Genomic DNA will be extracted from the blood samples and analysed by standard molecular biology techniques.The allelic and genotype frequencies of the two ICAM-1 variants will be calculated in the obese and control groups. The statistical significance of possible differences will be determined

Eligibility

Ages Eligible for Study:	18 Years to 60 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Obesity

Exclusion Criteria:

Associated inflammatory diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00436488

Sponsors and Collaborators

Istituto Auxologico Italiano

Investigators

Principal Investigator:

Anna Maria Di Blasio, MD

Istituto Auxologico Italiano

More Information

No publications provided

Study ID Numbers:	12C501
Study First Received:	February 16, 2007
Last Updated:	February 16, 2007
ClinicalTrials.gov Identifier:	NCT00436488 History of Changes
Health Authority:	Italy: Ethics Committee

Keywords provided by Istituto Auxologico Italiano:

ICAM-1
Obesity
Gene variants

Additional relevant MeSH terms:

Body Weight
Signs and Symptoms
Obesity

Nutrition Disorders
Overweight
Overnutrition

ClinicalTrials.gov processed this record on February 08, 2010